Association between History of Pregnancy and Liver Fibrosis Using Fibrosis-4 Index in Korean Postmenopausal Women: A Nationwide Population-Based Study
DC Field | Value | Language |
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dc.contributor.author | Ahn, Jae-Joon | - |
dc.contributor.author | Park, Joo-Hyun | - |
dc.contributor.author | Kim, Do-Hoon | - |
dc.contributor.author | Kim, Hyun-Jin | - |
dc.contributor.author | Ko, Hyung-Seok | - |
dc.contributor.author | Kwon, Jun-Yeon | - |
dc.contributor.author | Koh, Young-Sang | - |
dc.contributor.author | Jung, Jin-Hyung | - |
dc.contributor.author | Lee, Gyu-Na | - |
dc.contributor.author | Han, Kyungdo | - |
dc.date.accessioned | 2023-03-23T07:40:07Z | - |
dc.date.available | 2023-03-23T07:40:07Z | - |
dc.date.created | 2023-02-27 | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 2005-6443 | - |
dc.identifier.uri | http://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/43497 | - |
dc.description.abstract | Background: The association between a history of pregnancy and liver fibrosis remains unclear. Herein, we investi-gated the association between reproductive factors, including a history of pregnancy and liver fibrosis, in post-menopausal Korean women.Methods: This study used nationally representative, population-based data collected from the Korea National Health and Nutrition Examination Survey 2008-2017. Of 14,624 women with natural menopause, 11,085 with no previous history of any type of cancer, hepatitis, or chronic heavy alcohol consumption were enrolled. We investi-gated the reproductive factors, including a history of pregnancy, total reproductive years, age at menarche and menopause, and oral contraceptive use. Liver fibrosis was defined as a Fibrosis-4 index score >= 2.67 kg/m2.Results: Of the study participants, 372 (3.3%) had advanced liver fibrosis. Multivariable logistic regression analysis showed that women with a history of more than one pregnancy were associated with a lower risk of liver fibrosis compared to women who had never been pregnant, after adjusting for potential confounders (adjusted odds ratio, 0.30; 95% confidence interval, 0.15-0.59). The risk of liver fibrosis did not increase significantly with an increasing number of pregnancies (P for trend=0.135). Other reproductive factors, including total reproductive years, age at menopause and menarche, and oral contraceptive use, were not significantly associated with liver fibrosis.Conclusion: Postmenopausal women who had experienced one or more pregnancies had a reduced risk of liver fi-brosis. Our findings reveal a potential protective role of pregnancy against liver fibrosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD FAMILY MEDICINE | - |
dc.relation.isPartOf | KOREAN JOURNAL OF FAMILY MEDICINE | - |
dc.title | Association between History of Pregnancy and Liver Fibrosis Using Fibrosis-4 Index in Korean Postmenopausal Women: A Nationwide Population-Based Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.4082/kjfm.21.0177 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF FAMILY MEDICINE, v.43, no.6, pp.388 - 395 | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000919442700008 | - |
dc.identifier.scopusid | 2-s2.0-85143762654 | - |
dc.citation.endPage | 395 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 388 | - |
dc.citation.title | KOREAN JOURNAL OF FAMILY MEDICINE | - |
dc.citation.volume | 43 | - |
dc.contributor.affiliatedAuthor | Han, Kyungdo | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | Pregnancy | - |
dc.subject.keywordAuthor | Liver Cirrhosis | - |
dc.subject.keywordAuthor | Post-Menopause | - |
dc.subject.keywordAuthor | Women | - |
dc.subject.keywordAuthor | Reproductive History | - |
dc.subject.keywordPlus | CHRONIC HEPATITIS-C | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ESTROGEN | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | RISK | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Primary Health Care | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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