Functional poly(l-lysine) derivative nanogels with acidic pH-pulsed antitumor drug release properties
- Authors
- Lee, M.J.; Oh, N.M.; Oh, K.T.; Youn, Y.S.; Lee, E.S.
- Issue Date
- 1-Oct-2014
- Publisher
- Kluwer Academic Publishers
- Keywords
- 3-(Diethylamino)propyl; Antitumor drug delivery; Genipin; pH-Responsive nanogels
- Citation
- Journal of Pharmaceutical Investigation, v.44, no.5, pp 351 - 356
- Pages
- 6
- Journal Title
- Journal of Pharmaceutical Investigation
- Volume
- 44
- Number
- 5
- Start Page
- 351
- End Page
- 356
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/13791
- DOI
- 10.1007/s40005-014-0130-7
- ISSN
- 2093-5552
2093-6214
- Abstract
- We developed novel poly(l-lysine) [poly(Lys)] derivative nanogels with smart drug release properties. Poly(Lys) derivative was prepared after the chemical reaction of poly(Lys) and 3-diethylaminopropyl isothiocyanate (DEAP), and was coupled with poly(ethylene glycol) (PEG). The obtained poly(Lys-DEAP)-b-PEG was crosslinked by genipin (crosslinking agent) in an oil/water emulsion condition, producing poly(Lys) derivative nanogels. These nanogels (~95 nm in diameter, pH 7.4) showed volume expansion (~200 nm in diameter) in the endosomal pH (~pH 6.0) due to extensive proton absorption of DEAP moieties in the crosslinked nanogel core. These nanogels reversibly swelled at pH 6.0 and shrank at pH 7.4, correspond to maximized drug release at pH 6.0 and minimized drug release at pH 7.4. We conclude that this nanogel system will have great potential for tumor therapy. © 2014, The Korean Society of Pharmaceutical Sciences and Technology.
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