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Aldose reductase inhibition by luteolin derivatives from Parasenecio pseudotaimingasaAldose Reductase Inhibition by Luteolin Derivatives from Parasenecio pseudotaimingasa
- Issue Date
- Dec-2011
- Publisher
- 한국생약학회
- Keywords
- Luteolin-7-o-glucoside; Luteolin-7-O-rutinoside; Parasenecio pseudotaimingasa; Senecioneae
- Citation
- Natural Product Sciences, v.17, no.4, pp 367 - 371
- Pages
- 5
- Journal Title
- Natural Product Sciences
- Volume
- 17
- Number
- 4
- Start Page
- 367
- End Page
- 371
- ISSN
- 1226-3907
- Abstract
- Effects of the extract and fractions from Parasenecio pseudotaimingasa on rat lens aldose reductase (AR) inhibition have been investigated. Among them, the n-BuOH fraction was exhibited good inhibitory potencies (IC 50 value 1.42 μg/ml). Phytochemical constituents were isolated from the n-BuOH fraction by open column chromatography. Their structures were elucidated as luteolin-7-O-rutinoside (1) and luteolin-7-Oglucoside (2) on the basis of spectroscopic analysis. Compounds 1 and 2 exhibited strong AR inhibitory activity, with IC 50 values of 2.37 and 1.05 μM, respectively. This is the first report on the isolation of compounds 1 and 2 from P. pseudotaimingasa. These results suggest that P. pseudotaimingasa could be a useful material in the development of a novel AR inhibitory agent against diabetic complications.
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