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Delphinidin Ameliorates Beta-Amyloid-Induced Neurotoxicity by Inhibiting Calcium Influx and Tau Hyperphosphorylation
- Authors
- Kim, Hyo-Shin; Sul, Donggeun; Lim, Ji-Youn; Lee, Dongho; Joo, Seong Soo; Hwang, Kwang Woo; Park, So-Young
- Issue Date
- Jul-2009
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- delphinidin; beta-amyloid; calcium influx; tau hyperphosphorylation; PC12 cells
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.73, no.7, pp 1685 - 1689
- Pages
- 5
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 73
- Number
- 7
- Start Page
- 1685
- End Page
- 1689
- ISSN
- 0916-8451
1347-6947
- Abstract
- Beta-amyloid (A beta) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against A beta-induced toxicity. A beta (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from A beta by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against A beta-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.
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