A case of allopurinol hypersensitivity syndrome

Abstract

Allopurinol(4-hydroxypyrazolo[3,4-d]pyrimidine) is an analog of hypoxanthine, widely used in the treatment of gout and in some patients develop the allopurinol hypersensitivity syndrome. Allopurinol hypersensitivity syndrome is characterized by multiple symptoms and signs such as fever, rash, decreased renal function, hepatocellular injury, leukocytosis, and eosinophilia. Herein reported is a 44 year-old male patient who developed generalized erythematous skin eruption with severe hepatotoxicity 3 weeks after taking allopurinol medication. The patient improved by dropping the allopurinol medication, which was consistent with the allopurinol hypersensitivity syndrome.