A case of skin necrosis due to adriamycin extravasation

Abstract

Adriamycin extravasation into subcutaneous tissues during intravenous administration results in an intense inflammatory response, which may progress to full thickness skin loss. With increased use of the potent anticancer drug adriamycin, there are increasing numbers of severe local tissue damage at the venous administration sites. We report a case of skin necrosis that was caused by extravasation of adriamycin in the treatment of multiple myeloma. When anticancer drug extravasation occurs, early recognition and adequate management is required.