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Cited 26 time in webofscience Cited 29 time in scopus
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Enhanced tendon restoration effects of anti-inflammatory, lactoferrin-immobilized, heparin-polymeric nanoparticles in an Achilles tendinitis rat model

Authors
Choi, Hong JoonChoi, SomangKim, Jae GyoonSong, Mi HyunShim, Kyu-SikLim, Youn-MookKim, Hak-JunPark, KyeongsoonKim, Sung Eun
Issue Date
1-Aug-2020
Publisher
ELSEVIER SCI LTD
Keywords
sustained lactoferrin delivery; nanoparticles; tenocytes; inflammatory factors; tendon healing
Citation
CARBOHYDRATE POLYMERS, v.241
Journal Title
CARBOHYDRATE POLYMERS
Volume
241
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/41749
DOI
10.1016/j.carbpol.2020.116284
ISSN
0144-8617
1879-1344
Abstract
Gradual wear and tear can cause a local inflammatory response in tendons. The trauma and inflammatory reaction eventually impair the biomechanical properties of the tendon. In this study, we prepared lactoferrinimmobilized, heparin-anchored, poly(lactic-co-glycolic acid) nanoparticles (LF/Hep-PLGA NPs) and evaluated their in vitro anti-inflammatory effects on interleukin-1 beta (IL-1 beta)-treated tenocytes and in vivo tendon healing effects in a rat model of Achilles tendinitis. Long-term LF-deliverable NPs (LF/Hep-PLGA NPs) remarkably decreased mRNA levels of pro-inflammatory factors [cyclooxygenase-2 (COX-2), IL-1 beta, matrix metalloproteinase-3 (MMP-3), MMP-13, IL-6, and tumor necrosis factor-alpha (TNF-alpha)] and increased mRNA levels of anti-inflammatory cytokines (IL-4 and IL-10) in both IL-1 beta-treated tenocytes and the Achilles tendons of a collagenase-induced Achilles tendinitis rat model. Interestingly, anti-inflammatory LF/Hep-PLGA NPs greatly enhanced collagen content, mRNA levels of tenogenic markers [collagen type I (COL1A1), decorin (DCN), tenascin-C (TNC)], and biomechanical properties such as tendon stiffness and tensile strength. These results suggest that anti-inflammatory LF/Hep-PLGA NPs are effective at restoring tendons in Achilles tendinitis.
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Park, Kyeong Soon
생명공학대학 (시스템생명공학과)
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