https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/450 2026-04-04T10:43:27Z 2026-04-04T10:43:27Z Yi, Kyu-Ho Lee, Siyun Lee, Ji-Hyun Lee, Hyung-Jin https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89479 2023-10-29T13:40:22Z 2023-09-01T00:00:00Z

Title: Observation of Anatomical Structures in the Human Larynx Using Micro-Computed Tomography with Lugol's Solution Enhancement Authors: Yi, Kyu-Ho; Lee, Siyun; Lee, Ji-Hyun; Lee, Hyung-Jin Abstract: Histological and naked-eye dissections are frequently used to investigate human anatomy. However, limitations of conventional methods include tissue damage and difficulty in observing structures, rendering findings limited. Micro-computed tomography (micro-CT) allows for a three-dimensional observation with whole-mount staining for contrast enhancement. A precise anatomical understanding of the larynx is essential for both the medical and surgical fields; however, the larynx is difficult to dissect because of its minuscule and complex structures. Therefore, we aimed to clarify the detailed anatomy of the larynx using micro-CT. The study was conducted on twelve specimens of cadavers using Lugol-based-contrast micro-CT. Using Lugol-micro-CT, relevant information on human structures was obtained. Consequently, we successfully employed the Lugol-micro-CT technique in the analysis of specific human soft tissue structures that are challenging to analyze using conventional methods.

2023-09-01T00:00:00Z 정아람 https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89459 2023-10-26T01:40:21Z 2023-08-01T00:00:00Z

Title: 한약의 아토피피부염에 대한 국내외 동물실험 연구 동향: 최근 10년을 중심으로 Authors: 정아람 Abstract: Objectives The aim of this study was to analyze the research trends in herbal medicine as a treatment for atopic dermatitis (AD) in an animal model. Methods We conducted a search targeting papers published from 2013 onwards in Korean and English databases. The search terms were focused on “AD”, “dermatitis”, and “Korean medicine”. Only animal experimental studies involving the oral administration of single or complex prescriptions of Korean medicine were included, whereas in vitro studies, local administration studies, and studies of specific components of Korean medicine were excluded. We searched the PubMed and Embase databases for English databases and the Science on Research Information Sharing Service (RISS) and Korean Studies Information Service System (KISS) databases for Korean studies. Results Among the herbal medicine intervention groups, the most commonly used single herbs were baekseonpi, danggui, and douchi, whereas a mixture of hwangryun and gamcho was used in three studies, making it the most frequently used combination. There were significant improvements in indicators related to the symptoms of AD and various pro-inflammatory markers. Conclusions These results indicate the efficacy of herbal medicines in the treatment of AD in animal models. However, this study had several limitations. Therefore, future systematic reviews that address these limitations and provide more comprehensive analyses are required.

2023-08-01T00:00:00Z Jo, Hee-Geun Baek, Chae Yun Kim, Donghwan Lee, Donghun Song, Ho Sueb https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89443 2023-10-25T00:40:48Z 2023-09-01T00:00:00Z

Title: Stem of Sorbus commixta Hedl. Extract Inhibits Cartilage Degradation and Arthritic Pain in Experimental Model via Anti-Inflammatory Activity Authors: Jo, Hee-Geun; Baek, Chae Yun; Kim, Donghwan; Lee, Donghun; Song, Ho Sueb Abstract: Osteoarthritis (OA) is a widespread joint disease that affects millions of people worldwide. Conventional treatments for OA, including non-steroidal anti-inflammatory drugs (NSAIDs) and steroids, have a risk of various adverse events, including liver, gastrointestinal, cardiovascular, and kidney disease, which are unsatisfactory in their effectiveness. In this study, Sorbus commixta Hedl. Stem extracts (SCE) were evaluated in animal models as potential inhibitors for the progression of OA. Sorbus commixta Hedl., which was found to have substantial anti-inflammatory and antioxidant activities in earlier investigations, has shown potential as a candidate for OA treatment. To mimic human OA symptoms, male rats were injected using sodium iodoacetate (MIA) in their knee joints. SCE significantly reduced MIA-induced weight-bearing loss in rats after the MIA injection and alleviated cartilage degradation and subchondral bone injury caused by MIA. In addition, SCE administration reduced levels of TNF-alpha and IL-1 beta such as pro-inflammatory cytokines in serum, as well as the levels of matrix metalloproteinases (MMPs) such as MMP-1, -3, -8 and -13 in the joint cartilage. SCE significantly inhibited the writhing responses in acetic acid-administered mice and was used to quantify pain. In lipopolysaccharide (LPS)-activated RAW264.7, SCE suppressed NO production and reduced the expression of TNF-alpha, PGE2, IL-6, IL-1 beta, MMP1, MMP3, MMP8, and MMP-13. Our study showed that SCE alleviated inflammation and cartilage degradation in arthritis through its anti-inflammatory activities on multiple targets.

2023-09-01T00:00:00Z Min, Su Ji Kim, Sung Jin Park, Jun Yeon Seo, Chang-Seob Choi, You-Kyong https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89387 2023-12-11T06:31:05Z 2023-09-01T00:00:00Z

Title: Preparation of Herbal Extracts for Intestinal Immune Modulation Activity Based on In Vitro Screening and In Vivo Evaluation of Zingiber officinale Rosc. Extracts Authors: Min, Su Ji; Kim, Sung Jin; Park, Jun Yeon; Seo, Chang-Seob; Choi, You-Kyong Abstract: Ten traditional herbal extracts effective against diarrhea, infectious diseases, and bacterial activity were selected and analyzed for Peyer's patch cell-mediated intestinal immunomodulatory activity in vitro and in vivo. Among the 10 herbal extracts, Zingiber officinale Rosc. (ZO) extract induced the highest secretion of immunoglobulin A (IgA) and granulocyte macrophage colony-stimulating factor (GM-CSF) in the cells of Peyer's patches. Furthermore, animal experiments showed that IA production was enhanced with the oral administration of ZO extract (100 mg/kg and 300 mg/kg) for 10 days. In addition, 6-, 8-, 10-gingerol, and 6-, 8-, 10-shogaol, the six major index compounds of ZO extract, were analyzed using HPLC. Our study findings confirm the intestinal immunomodulatory activity of ZO extract and lay a strong foundation for future analytical studies aimed at determining the active components of ZO extracts.

2023-09-01T00:00:00Z