https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/800 Sat, 04 Apr 2026 07:20:57 GMT 2026-04-04T07:20:57Z https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89225 Title: SAM-Support-Based Electrochemical Sensor for A beta Biomarker Detection of Alzheimer's Disease Authors: Le, Phan Gia; Le, Hien T. Ngoc; Kim, Hee-Eun; Cho, Sungbo Abstract: Alzheimer's disease has taken the spotlight as a neurodegenerative disease which has caused crucial issues to both society and the economy. Specifically, aging populations in developed countries face an increasingly serious problem due to the increasing budget for patient care and an inadequate labor force, and therefore a solution is urgently needed. Recently, diverse techniques for the detection of Alzheimer's biomarkers have been researched and developed to support early diagnosis and treatment. Among them, electrochemical biosensors and electrode modification proved their effectiveness in the detection of the A beta biomarker at appropriately low concentrations for practice and point-of-care application. This review discusses the production and detection ability of amyloid beta, an Alzheimer's biomarker, by electrochemical biosensors with SAM support for antibody conjugation. In addition, future perspectives on SAM for the improvement of electrochemical biosensors are also proposed and discussed. Tue, 01 Aug 2023 00:00:00 GMT https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89225 2023-08-01T00:00:00Z https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88415 Title: Effects of stretching intervention on musculoskeletal pain in dental professionals Authors: Kim, Eun-Sol; Jo, Eun-Deok; Han, Gyeong-Soon Abstract: Objective: This study aimed to quantitatively confirm the effects of dental specialists' work and stretching on musculoskeletal pain.Methods: The pain pressure threshold was divided into five parts (neck, shoulder, trunk, lower back, and hand/arm) of the upper body and measured at 15 muscle trigger points. The pain pressure threshold before and after work was measured, and 30 min of stretching and rest were stipulated as an intervention.Results: The pain pressure thresholds reduced significantly in all muscles after work (P < .05). In the stretching group, the pain pressure thresholds increased significantly in all muscles (P < .05). In particular, the iliocostalis lumborum (lower back), rhomboid (trunk), transverse carpal ligament (hand/arm), levator scapulae-superior angle (neck), and upper trapezius (shoulder) muscles showed the greatest decrease in pain pressure threshold after work and the greatest increase after stretching.Conclusions: Stretching helps immediately relieve musculoskeletal pain in dental professionals and can prevent and manage work-related musculoskeletal disorders. Sun, 01 Jan 2023 00:00:00 GMT https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88415 2023-01-01T00:00:00Z https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88109 Title: Developmental function of Piezo1 in mouse submandibular gland morphogenesis Authors: Pokharel, Elina; Aryal, Yam Prasad; Kim, Tae-Young; Kim, Anna; Kim, Ji-Youn; Yamamoto, Hitoshi; Cho, Sung-Won; Sohn, Wern-Joo; Kim, Jae-Young; Jung, Jae-Kwang Abstract: Mechanically activated factors are important in organogenesis, especially in the formation of secretory organs, such as salivary glands. Piezo-type mechanosensitive ion channel component 1 (Piezo1), although previously studied as a physical modulator of the mechanotransduction, was firstly evaluated on its developmental function in this study. The detailed localization and expression pattern of Piezo1 during mouse submandibular gland (SMG) development were analyzed using immunohistochemistry and RT-qPCR, respectively. The specific expression pattern of Piezo1 was examined in acinar-forming epithelial cells at embryonic day 14 (E14) and E16, which are important developmental stages for acinar cell differentiation. To understand the precise function of Piezo1 in SMG development, siRNA against Piezo1 (siPiezo1) was employed as a loss-of-function approach, during in vitro organ cultivation of SMG at E14 for the designated period. Alterations in the histomorphology and expression patterns of related signaling molecules, including Bmp2, Fgf4, Fgf10, Gli1, Gli3, Ptch1, Shh, and Tgf beta-3, were examined in acinar-forming cells after 1 and 2 days of cultivation. Particularly, altered localization patterns of differentiation-related signaling molecules including Aquaporin5, E-cadherin, Vimentin, and cytokeratins would suggest that Piezo1 modulates the early differentiation of acinar cells in SMGs by modulating the Shh signaling pathway. Thu, 01 Jun 2023 00:00:00 GMT https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88109 2023-06-01T00:00:00Z https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87915 Title: 설치류의 연하 근육의 발생학적 고찰 Authors: 주시은; 김재영; 정재광; 김지연 Abstract: Objectives: The aim of this study was to provide a developmental understanding of the swallowing muscles in rodents. Methods: A review of the similarities and differences in swallowing between human and rodents, and the development of swallowing muscles in rodents, was executed. Results: It was confirmed that swallowing in humans and rodents is biologically similar. A summary of the development process and anatomical structure of the muscles involved in swallowing was provided. Conclusions: The developmental understanding of the muscles and anatomical structure related to swallowing in rodents can be used as basic data for developmental biological research on the regeneration of swallowing muscles. In future studies, further investigation of the developmental origins of muscles related to swallowing may help provide additional understandings of swallowing muscle regeneration for treatment of dysphagia. Wed, 01 Mar 2023 00:00:00 GMT https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87915 2023-03-01T00:00:00Z