Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity
DC Field | Value | Language |
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dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Moon, Eunjung | - |
dc.contributor.author | Lee, Seoung Rak | - |
dc.contributor.author | Park, Kyoung Jin | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T07:44:05Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 0103-5053 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10000 | - |
dc.description.abstract | As part of our ongoing search for bioactive constituents of natural Korean medicinal resources, a bioassay-guided fractionation and chemical investigation of the MeOH extract of Raphanus sativus (Brassicaceae) seeds resulted in the isolation and identification of fifteen compounds, including a new phenolic compound. The structure of the new compound was determined by extensive spectroscopic analysis and the Mosher's method. One of the compounds has been recently reported as a synthetic product. Some compounds showed moderate antiproliferative activities against the tumor cell lines A549, SK-OV-3, SK-MEL-2, and HCT-15 with IC50 values in the range of 5.62 to 28.88 mu M. Moreover, the anti-neuroinflammatory activities of the isolates were determined by measuring the nitric oxide (NO) levels in the medium using murine microglia BV-2 cells. With exception of one specific compound, all the others inhibited the lipopolysaccharide (LPS)-stimulated NO production (IC50 values < 200 mu M). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SOC BRASILEIRA QUIMICA | - |
dc.relation.isPartOf | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | - |
dc.subject | ACID | - |
dc.subject | GLUCOSINOLATE | - |
dc.title | Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000366098700017 | - |
dc.identifier.doi | 10.5935/0103-5053.20150222 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v.26, no.11, pp.2307 - 2312 | - |
dc.identifier.scopusid | 2-s2.0-84946033968 | - |
dc.citation.endPage | 2312 | - |
dc.citation.startPage | 2307 | - |
dc.citation.title | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | - |
dc.citation.volume | 26 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Raphanus sativus | - |
dc.subject.keywordAuthor | Brassicaceae | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | Mosher&apos | - |
dc.subject.keywordAuthor | s method | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | GLUCOSINOLATE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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