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Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity

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dc.contributor.authorKim, Ki Hyun-
dc.contributor.authorMoon, Eunjung-
dc.contributor.authorLee, Seoung Rak-
dc.contributor.authorPark, Kyoung Jin-
dc.contributor.authorKim, Sun Yeou-
dc.contributor.authorChoi, Sang Un-
dc.contributor.authorLee, Kang Ro-
dc.date.available2020-02-28T07:44:05Z-
dc.date.created2020-02-06-
dc.date.issued2015-11-
dc.identifier.issn0103-5053-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10000-
dc.description.abstractAs part of our ongoing search for bioactive constituents of natural Korean medicinal resources, a bioassay-guided fractionation and chemical investigation of the MeOH extract of Raphanus sativus (Brassicaceae) seeds resulted in the isolation and identification of fifteen compounds, including a new phenolic compound. The structure of the new compound was determined by extensive spectroscopic analysis and the Mosher's method. One of the compounds has been recently reported as a synthetic product. Some compounds showed moderate antiproliferative activities against the tumor cell lines A549, SK-OV-3, SK-MEL-2, and HCT-15 with IC50 values in the range of 5.62 to 28.88 mu M. Moreover, the anti-neuroinflammatory activities of the isolates were determined by measuring the nitric oxide (NO) levels in the medium using murine microglia BV-2 cells. With exception of one specific compound, all the others inhibited the lipopolysaccharide (LPS)-stimulated NO production (IC50 values < 200 mu M).-
dc.language영어-
dc.language.isoen-
dc.publisherSOC BRASILEIRA QUIMICA-
dc.relation.isPartOfJOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY-
dc.subjectACID-
dc.subjectGLUCOSINOLATE-
dc.titleChemical Constituents of the Seeds of Raphanus sativus and their Biological Activity-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000366098700017-
dc.identifier.doi10.5935/0103-5053.20150222-
dc.identifier.bibliographicCitationJOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v.26, no.11, pp.2307 - 2312-
dc.identifier.scopusid2-s2.0-84946033968-
dc.citation.endPage2312-
dc.citation.startPage2307-
dc.citation.titleJOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY-
dc.citation.volume26-
dc.citation.number11-
dc.contributor.affiliatedAuthorKim, Sun Yeou-
dc.type.docTypeArticle-
dc.subject.keywordAuthorRaphanus sativus-
dc.subject.keywordAuthorBrassicaceae-
dc.subject.keywordAuthorcytotoxicity-
dc.subject.keywordAuthoranti-inflammation-
dc.subject.keywordAuthorMosher&apos-
dc.subject.keywordAuthors method-
dc.subject.keywordPlusACID-
dc.subject.keywordPlusGLUCOSINOLATE-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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