Comprehensive geriatric assessment in elderly patients with newly diagnosed aggressive non-Hodgkin lymphoma treated with multi-agent chemotherapy
DC Field | Value | Language |
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dc.contributor.author | Park, Seha | - |
dc.contributor.author | Hong, Junshik | - |
dc.contributor.author | Hwang, Incheol | - |
dc.contributor.author | Ahn, Jeong-Yeal | - |
dc.contributor.author | Cho, Eun Yeong | - |
dc.contributor.author | Park, Finny | - |
dc.contributor.author | Cho, Eun Kyung | - |
dc.contributor.author | Shin, Dong Bok | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.date.available | 2020-02-28T07:44:06Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 1879-4068 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10001 | - |
dc.description.abstract | Objectives: The purpose of this prospective observational study is to evaluate the relation of the comprehensive geriatric assessment (CGA) to tolerability and survival of multi-agent chemotherapy for curative intent in elderly patients with aggressive non-Hodgkin lymphoma (NHL). Materials and Methods: Patients who were 1) age >= 65 years, 2) newly diagnosed aggressive NHL, and 3) treated with multi-agent chemotherapy within 2 weeks from the time of diagnosis were enrolled from January 2011 to June 2014. Baseline clinical, laboratory, and CGA data being composed of Mini Nutritional Assessment-Short Form (MNA-SF), Korean version of Mini Mental Status Exam, Korean-Geriatric Depression Scale, and Groningen Frailty Index (GFI), were collected and analyzed for the relation to the outcome factors. Results: Seventy patients were included; the median age was 73.5 years, 27 (38.6%) patients were Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 2 or more, and half of the patients were high or high-intermediate risk by age-adjusted international prognostic index (aaIPI). Most patients received CHOP or CHOP-like chemotherapy. Factors affecting discontinuation of chemotherapy within 12 weeks were poor MNA-SF, poor GFI, poor PS, and presence of B symptom. Among those, poor MNA-SF was independent of other variables in multivariate analysis. Poor MNA-SF, bone marrow involvement, and baseline anemia of hemoglobin < 10 g/dL were found to be independent factors associated with inferior overall survival whereas aaIPI factors were not. Conclusion: MNA-SF predicted tolerability to multi-agents chemotherapy and overall survival in elderly patients with aggressive NHL who were treated with multi-agent chemotherapy. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | JOURNAL OF GERIATRIC ONCOLOGY | - |
dc.subject | B-CELL LYMPHOMA | - |
dc.subject | MINI-NUTRITIONAL ASSESSMENT | - |
dc.subject | OLDER CANCER-PATIENTS | - |
dc.subject | MENTAL-STATE | - |
dc.subject | FEASIBILITY | - |
dc.subject | COMORBIDITY | - |
dc.subject | INTENSITY | - |
dc.subject | THERAPY | - |
dc.title | Comprehensive geriatric assessment in elderly patients with newly diagnosed aggressive non-Hodgkin lymphoma treated with multi-agent chemotherapy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000365929600008 | - |
dc.identifier.doi | 10.1016/j.jgo.2015.10.183 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GERIATRIC ONCOLOGY, v.6, no.6, pp.470 - 478 | - |
dc.identifier.scopusid | 2-s2.0-84949994730 | - |
dc.citation.endPage | 478 | - |
dc.citation.startPage | 470 | - |
dc.citation.title | JOURNAL OF GERIATRIC ONCOLOGY | - |
dc.citation.volume | 6 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Park, Seha | - |
dc.contributor.affiliatedAuthor | Hong, Junshik | - |
dc.contributor.affiliatedAuthor | Hwang, Incheol | - |
dc.contributor.affiliatedAuthor | Ahn, Jeong-Yeal | - |
dc.contributor.affiliatedAuthor | Cho, Eun Yeong | - |
dc.contributor.affiliatedAuthor | Cho, Eun Kyung | - |
dc.contributor.affiliatedAuthor | Shin, Dong Bok | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Non-Hodgkin lymphoma | - |
dc.subject.keywordAuthor | Geriatric assessment | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | Elderly | - |
dc.subject.keywordPlus | B-CELL LYMPHOMA | - |
dc.subject.keywordPlus | MINI-NUTRITIONAL ASSESSMENT | - |
dc.subject.keywordPlus | OLDER CANCER-PATIENTS | - |
dc.subject.keywordPlus | MENTAL-STATE | - |
dc.subject.keywordPlus | FEASIBILITY | - |
dc.subject.keywordPlus | COMORBIDITY | - |
dc.subject.keywordPlus | INTENSITY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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