Antineuroinflammatory and Antiproliferative Activities of Constituents from Tilia amurensis
DC Field | Value | Language |
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dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Moon, Eunjung | - |
dc.contributor.author | Cha, Joon Min | - |
dc.contributor.author | Lee, Seulah | - |
dc.contributor.author | Yu, Jae Sik | - |
dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T07:45:52Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10098 | - |
dc.description.abstract | As part of our ongoing search for bioactive constituents of natural Korean medicinal resources, we found in a preliminary study that the methanol (MeOH) extract from the trunks of Tilia amurensis RUPR. showed an inhibitory effect on nitric oxide (NO) production in an activated murine microglial cell line. A bioassay-guided fractionation and chemical investigation of the MeOH extract resulted in the isolation and identification of a new isoflavonoid glycoside, orobol 4'-O-beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside (1) and 16 known compounds (2-17). The structure of the new compound was determined by spectroscopic methods, i.e., one-dimensional (1D) and two-dimensional (2D)-NMR techniques and high resolution (HR)-MS, and chemical methods. The antineuroinflammatory activities of the isolated compounds were determined by measuring NO levels in the medium using murine microglial BV-2 cells. Among them, 12 compounds, including compound 1 (most active with an IC50 value of 23.42 mu M), inhibited NO production in lipopolysaccharide-stimulated BV-2 cells. Moreover, compounds 1-4 showed moderate antiproliferative activities against the SK-MEL-2 cell line, with IC50 values ranging from 12.31 to 19.67 mu M. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.relation.isPartOf | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | CHEMICAL-CONSTITUENTS | - |
dc.subject | GLYCOSIDES | - |
dc.subject | MICROGLIA | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | ISOFLAVONES | - |
dc.subject | INHIBITION | - |
dc.subject | INJURY | - |
dc.subject | DEATH | - |
dc.subject | CELLS | - |
dc.title | Antineuroinflammatory and Antiproliferative Activities of Constituents from Tilia amurensis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000362047000012 | - |
dc.identifier.doi | 10.1248/cpb.c15-00393 | - |
dc.identifier.bibliographicCitation | CHEMICAL & PHARMACEUTICAL BULLETIN, v.63, no.10, pp.837 - 842 | - |
dc.identifier.scopusid | 2-s2.0-84947601791 | - |
dc.citation.endPage | 842 | - |
dc.citation.startPage | 837 | - |
dc.citation.title | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 63 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Moon, Eunjung | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Tilia amurensis | - |
dc.subject.keywordAuthor | Tiliaceae | - |
dc.subject.keywordAuthor | isoflavonoid glycoside | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | antineuroinflammation | - |
dc.subject.keywordAuthor | antiproliferation | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | CHEMICAL-CONSTITUENTS | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | MICROGLIA | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | ISOFLAVONES | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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