Quantification of bone regeneration by virtual slices using non-destructive synchrotron X-ray microtomography
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong-Gun | - |
dc.contributor.author | Bark, Chung Wung | - |
dc.date.available | 2020-02-28T07:45:59Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10102 | - |
dc.description.abstract | This study demonstrates a non-destructive histomorphometric analysis technique that uses virtual tissue slices obtained with synchrotron radiation X-ray microtomography (SR-mu CT), and compared the results to those obtained using conventional hematoxylin-eosin (H&E) photomicrography of regenerated bone in rat calvarial defects grafted with deproteinized bovine bone substitute (Bio-Oss(A (R))). Calvarial defects (diameter, 4 mm) were created in 8 adult male Spraque-Dawley rats and filled with Bio-Oss(A (R)). The percentage of newly formed bone (NB%) was evaluated histomorphometrically using SR-mu CT images and photomicrographs (H&E) 3 weeks postoperatively. Osteoconductive new bone formation was observed in the calvarial central defect. Histomorphometric analysis revealed no NB% differences between the SR-mu CT and photomicrograph (H&E) groups at 3 weeks (p=0.959). The mean new bone area fractions were 17.62% and 17.95% in the analysis using SR-mu CT virtual slices and conventional H&E-stained slices, respectively. Therefore, Bio-Oss(A (R)) bone regeneration can be quantified non-destructively using SR-mu CT at an accuracy comparable to that obtained using conventional photomicrography. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | - |
dc.relation.isPartOf | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.subject | CALCIUM-PHOSPHATE CERAMICS | - |
dc.subject | COMPUTED-TOMOGRAPHY | - |
dc.subject | GRAFT SUBSTITUTES | - |
dc.subject | RADIATION | - |
dc.subject | DEFECTS | - |
dc.subject | TISSUES | - |
dc.subject | CT | - |
dc.title | Quantification of bone regeneration by virtual slices using non-destructive synchrotron X-ray microtomography | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000363534000011 | - |
dc.identifier.doi | 10.1007/s13770-015-0003-9 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.12, no.5, pp.379 - 385 | - |
dc.identifier.kciid | ART002036544 | - |
dc.identifier.scopusid | 2-s2.0-84944744659 | - |
dc.citation.endPage | 385 | - |
dc.citation.startPage | 379 | - |
dc.citation.title | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Bark, Chung Wung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Bone substitute | - |
dc.subject.keywordAuthor | Radiation X-ray microtomography | - |
dc.subject.keywordAuthor | Photomicrograph (H& | - |
dc.subject.keywordAuthor | E) | - |
dc.subject.keywordAuthor | Histomorphometry | - |
dc.subject.keywordPlus | CALCIUM-PHOSPHATE CERAMICS | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | GRAFT SUBSTITUTES | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | DEFECTS | - |
dc.subject.keywordPlus | TISSUES | - |
dc.subject.keywordPlus | CT | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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