Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug
DC Field | Value | Language |
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dc.contributor.author | Battogtokh, Gantumur | - |
dc.contributor.author | Kang, Ji Hee | - |
dc.contributor.author | Ko, Young Tag | - |
dc.date.available | 2020-02-28T07:46:01Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 0939-6411 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10105 | - |
dc.description.abstract | The objective of this study was to develop an albumin nanoparticle with improved stability and drug loading capacity. Generation of nanomaterials having physiologically stable and high potential for drug delivery is still challenging. Herein we synthesized cholesteryl albumin conjugate using N,N-disuccinimidyl carbonate coupling reagent and prepared paclitaxel-loaded cholesteryl albumin nanoparticle (PTX-Chol-BSA) by self-assembly with the mean hydrodynamic diameter of 147.6 +/- 1.6 nm and with high loading capacity. PTX-Chol-BSA nanoparticle showed much higher colloidal stability than a simple complex of PTX and BSA (FrX-BSA) and sustained release profile. PTX-Chol-BSA nanoparticles exhibited greater cellular uptake and cytotoxicity in B16F10 and MCF-7 cancer cell lines, as compared with PTX in Cremophor EL/ethanol (PTX-Cre/EtOH) and PTX-BSA formulations. A pharmacokinetic study in tumor-bearing mice showed that the area under the concentration-time curve (AUC(0-8) (h)) following the administration of PTX-Chol-BSA was 1.6-2-fold higher than those following the administration of PTX-Cre/EtOH and PTX-BSA. In addition, the tumor AUC(0-8 h) of PTX-Chol-BSA was around 2-fold higher than that of PTX-BSA. Furthermore, in vivo antitumor efficacy results revealed that PTX-Chol-BSA nanoparticles have greater antitumor efficacy. In conclusion, we demonstrated the potential of PTX-Chol-BSA nanoparticles for anti-tumor chemotherapy, with enhanced in vitro and in vivo behaviors, as compared to PTX-BSA and PTX-Cre/EtOH. (C) 2015 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | BOUND PACLITAXEL | - |
dc.subject | DELIVERY | - |
dc.subject | CANCER | - |
dc.subject | THERAPEUTICS | - |
dc.subject | COPOLYMERS | - |
dc.subject | DOCETAXEL | - |
dc.subject | DIAGNOSIS | - |
dc.subject | CHITOSAN | - |
dc.subject | CARRIERS | - |
dc.title | Long-circulating self-assembled cholesteryl albumin nanoparticles enhance tumor accumulation of hydrophobic anticancer drug | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000364881900010 | - |
dc.identifier.doi | 10.1016/j.ejpb.2015.07.013 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v.96, pp.96 - 105 | - |
dc.identifier.scopusid | 2-s2.0-84938388018 | - |
dc.citation.endPage | 105 | - |
dc.citation.startPage | 96 | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | - |
dc.citation.volume | 96 | - |
dc.contributor.affiliatedAuthor | Battogtokh, Gantumur | - |
dc.contributor.affiliatedAuthor | Kang, Ji Hee | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Paclitaxel | - |
dc.subject.keywordAuthor | Albumin | - |
dc.subject.keywordAuthor | Self-assembled nanoparticle | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Cholesteryl BSA conjugate | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | BOUND PACLITAXEL | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.subject.keywordPlus | COPOLYMERS | - |
dc.subject.keywordPlus | DOCETAXEL | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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