Protective effects of HGF gene-expressing human mesenchymal stem cells in acetaminophen-treated hepatocytes
DC Field | Value | Language |
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dc.contributor.author | Jang, Yun Ho | - |
dc.contributor.author | You, Dong Hun | - |
dc.contributor.author | Nam, Myeong Jin | - |
dc.date.available | 2020-02-28T08:41:28Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-09-03 | - |
dc.identifier.issn | 0897-7194 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10137 | - |
dc.description.abstract | Mesenchymal stem cells (MSC) secrete a great variety of cytokines that have beneficial paracrine actions. Hepatocyte growth factor (HGF) promotes proliferation in several cell types. The aim of the present study was to investigate the protective effect of HGF gene-transfected MSC (HGF-MSC) in acetaminophen (AAP)-treated hepatocytes. We transfected the HGF gene into MSCs and confirmed HGF expression by RT-PCR and western blot. The concentration of HGF in HGF-MSC conditioned media (HGFCM) was upregulated compared with that in control MSCCM samples. Cell viability was increased in HGFCM-treated hepatocytes. Expression of Mcl-1, an anti-apoptosis protein, was increased and expression of pro-apoptosis proteins (Bad, Bik and Bid) was decreased in HGFCM-treated hepatocytes. HGF-MSC had protective effects on AAP-induced hepatocyte damage by enhancing proliferation. These results suggest that HGF-expressing MSCs may provide regenerative potential for liver cell damage. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | GROWTH FACTORS | - |
dc.subject | GROWTH-FACTOR GENE | - |
dc.subject | IN-VITRO | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | BONE-MARROW | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | REGENERATION | - |
dc.subject | RATS | - |
dc.subject | INHIBITION | - |
dc.subject | THERAPY | - |
dc.title | Protective effects of HGF gene-expressing human mesenchymal stem cells in acetaminophen-treated hepatocytes | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000368523900001 | - |
dc.identifier.doi | 10.3109/08977194.2015.1080695 | - |
dc.identifier.bibliographicCitation | GROWTH FACTORS, v.33, no.5-6, pp.319 - 325 | - |
dc.identifier.scopusid | 2-s2.0-84954471324 | - |
dc.citation.endPage | 325 | - |
dc.citation.startPage | 319 | - |
dc.citation.title | GROWTH FACTORS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 5-6 | - |
dc.contributor.affiliatedAuthor | Jang, Yun Ho | - |
dc.contributor.affiliatedAuthor | You, Dong Hun | - |
dc.contributor.affiliatedAuthor | Nam, Myeong Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Acetaminophen | - |
dc.subject.keywordAuthor | hepatocyte growth factor | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordAuthor | protection | - |
dc.subject.keywordPlus | GROWTH-FACTOR GENE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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