Anticancer Activity and Autophagy Involvement of Self-Assembled Arene-Ruthenium Metallacycles
DC Field | Value | Language |
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dc.contributor.author | Dubey, Abhishek | - |
dc.contributor.author | Jeong, Yong Joon | - |
dc.contributor.author | Jo, Jae Ho | - |
dc.contributor.author | Woo, Sangkook | - |
dc.contributor.author | Kim, Dong Hwan | - |
dc.contributor.author | Kim, Hyunuk | - |
dc.contributor.author | Kang, Se Chan | - |
dc.contributor.author | Stang, Peter J. | - |
dc.contributor.author | Chi, Ki-Whan | - |
dc.date.available | 2020-02-28T08:41:33Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-09-28 | - |
dc.identifier.issn | 0276-7333 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10139 | - |
dc.description.abstract | A suite of six metallacycles (16) was generated via coordination-driven self-assembly using the three dicarboxylate-bridged areneRu precursors [Ru-2(mu-eta(4)-OO boolean AND OO)(eta(6)-p-iPrC(6)H4Me)(2)][CF3SO3](2); (OO boolean AND OO = oxalate (A1), 2,5-dihydroxy-1,4-benzoquinonato (dobq) (A2), 5,8-dihydroxy-1,4-naphthoquinonato (donq) (A3); CF3SO3 = triflate) with one of two dipyridyl ligands (L1 and L2). The metallacycles were isolated in excellent yield (8692%) as triflate salts and characterized by proton (H-1) and carbon-13 (C-13) nuclear magnetic resonance (NMR) and electrospray ionizationmass spectrometry (ESI-MS) to confirm their structural assignments. Single-crystal X-ray crystal analysis of 1 revealed that two L1 ligands bridged two A1 acceptors to form a rectangular architecture. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was conducted to evaluate the in vitro cytotoxicities relative to two chemotherapeutic agents: namely, cisplatin and doxorubicin. Metallacycles 3 and 6 potently inhibited the growth of HCT-15 human colon and AGS human gastric cancer cells. The hollow fiber (HF) assay was performed to investigate the in vivo antitumor activities of metallacycles 3 and 6. Metallacycle 6 was more effective in inhibiting HCT-15 cells than metallacycle 3 in both in vitro and in vivo studies. Moreover, 3 and 6 induced autophagic activity in HCT-15 cells. These results suggested that the autophagic response elicited by metallacycles 3 and 6 could mediate the anticancer effects observed in human colorectal cancer cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ORGANOMETALLICS | - |
dc.subject | HOLLOW-FIBER ASSAY | - |
dc.subject | CANCER-CELLS | - |
dc.subject | TISSUE TRANSGLUTAMINASE | - |
dc.subject | BIOLOGICAL-ACTIVITY | - |
dc.subject | IN-VIVO | - |
dc.subject | COORDINATION-COMPLEXES | - |
dc.subject | MOLECULAR-RECTANGLES | - |
dc.subject | PANCREATIC-CANCER | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | DRUG | - |
dc.title | Anticancer Activity and Autophagy Involvement of Self-Assembled Arene-Ruthenium Metallacycles | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000362056400008 | - |
dc.identifier.doi | 10.1021/acs.organomet.5b00512 | - |
dc.identifier.bibliographicCitation | ORGANOMETALLICS, v.34, no.18, pp.4507 - 4514 | - |
dc.identifier.scopusid | 2-s2.0-84942546518 | - |
dc.citation.endPage | 4514 | - |
dc.citation.startPage | 4507 | - |
dc.citation.title | ORGANOMETALLICS | - |
dc.citation.volume | 34 | - |
dc.citation.number | 18 | - |
dc.contributor.affiliatedAuthor | Jeong, Yong Joon | - |
dc.contributor.affiliatedAuthor | Kang, Se Chan | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | HOLLOW-FIBER ASSAY | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | TISSUE TRANSGLUTAMINASE | - |
dc.subject.keywordPlus | BIOLOGICAL-ACTIVITY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | COORDINATION-COMPLEXES | - |
dc.subject.keywordPlus | MOLECULAR-RECTANGLES | - |
dc.subject.keywordPlus | PANCREATIC-CANCER | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | DRUG | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Inorganic & Nuclear | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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