Facile design and spectroscopic characterization of novel bio-inspired Quercetin-conjugated tetrakis (dimethylsulfoxide)dichlororuthenium(II) complex for enhanced anticancer properties
DC Field | Value | Language |
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dc.contributor.author | Lakshmi, Buddolla Anantha | - |
dc.contributor.author | Bae, Jin-Young | - |
dc.contributor.author | An, Jeong Ho | - |
dc.contributor.author | Kim, Sanghyo | - |
dc.date.available | 2020-02-27T02:22:23Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-09-01 | - |
dc.identifier.issn | 0020-1693 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1015 | - |
dc.description.abstract | A facile reflux approach was employed in the design of novel complexes using ruthenium(II) and quercetin for enhanced anticancer applications. The designed metal-based flavonoid complex was thoroughly characterized by employing powder XRD, H-1, C-13 NMR, elemental analysis (C, H, N, S, O), FT-IR, XPS, and UV-Vis spectroscopy techniques. The cell toxicity and cell proliferation properties of the Quercetin-Ru(II) complex were investigated on the non-small cell lung cancer cell lines (A549) along with the lung normal cells (WI-38) and human dermal fibroblast (HDFa) cells. Significant cytotoxicity was observed with the newly designed complex on A549 cells at minimum concentrations of (10-30 mu M). Interestingly, no remarkable cytotoxicity was observed in the WI-38 and HDFa cells. The same was confirmed by assessing cellular damage and nuclear damage via Atomic force microscopy (Bio-AFM) and Hoechst staining assay. Moreover, the results of intracellular reactive oxygen species (ROS) generation are also interesting to confirm the abilities of designed novel Quercetin-Ru(II) complex for anticancer applications. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE SA | - |
dc.relation.isPartOf | INORGANICA CHIMICA ACTA | - |
dc.subject | INDUCED GROWTH-INHIBITION | - |
dc.subject | LUNG-CANCER | - |
dc.subject | RUTHENIUM COMPLEX | - |
dc.subject | APOPTOSIS | - |
dc.subject | CELLS | - |
dc.subject | SUPPRESSES | - |
dc.subject | KAEMPFEROL | - |
dc.subject | INDUCTION | - |
dc.subject | DRUGS | - |
dc.title | Facile design and spectroscopic characterization of novel bio-inspired Quercetin-conjugated tetrakis (dimethylsulfoxide)dichlororuthenium(II) complex for enhanced anticancer properties | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000481728800054 | - |
dc.identifier.doi | 10.1016/j.ica.2019.118989 | - |
dc.identifier.bibliographicCitation | INORGANICA CHIMICA ACTA, v.495 | - |
dc.identifier.scopusid | 2-s2.0-85068205278 | - |
dc.citation.title | INORGANICA CHIMICA ACTA | - |
dc.citation.volume | 495 | - |
dc.contributor.affiliatedAuthor | Lakshmi, Buddolla Anantha | - |
dc.contributor.affiliatedAuthor | Kim, Sanghyo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Ruthenium(II) | - |
dc.subject.keywordAuthor | Quercetin | - |
dc.subject.keywordAuthor | Metal-based flavonoid | - |
dc.subject.keywordAuthor | Non-small cell lung cancer cell line | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Atomic force microscopy | - |
dc.subject.keywordPlus | INDUCED GROWTH-INHIBITION | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | RUTHENIUM COMPLEX | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SUPPRESSES | - |
dc.subject.keywordPlus | KAEMPFEROL | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | DRUGS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Inorganic & Nuclear | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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