Comparison of inhibitory activity of bioactive molecules on the dextransucrase from Streptococcus mutans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Choon Geun | - |
dc.contributor.author | Park, Jae Kweon | - |
dc.date.available | 2020-02-28T08:42:53Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 0175-7598 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10203 | - |
dc.description.abstract | The effect of chitosan with different molecular weights and other natural substances on dextransucrase (DSase) activity from a representative oral pathogen Streptococcus mutans was elucidated. Among other bioactive substances, amino-monosaccharides such as glucosamine, mannosamine, and galactosamine exerted the enzyme inhibitory activity over 95 % of DSase. The specified hydrolysates derived from the hydrolysis of high molecular weight chitosan (HMWC) designated to CTSN, CTSN-P, CTSN-B, and CTSN-S with different molecular weights ranging from 3 to 8 kDa showed the similar inhibitory activity toward DSase. Also, the hyaluronic acid (MW 8.9 kDa), sulfated chitin, and amino-monosaccharides demonstrated the significant activity, CTSN, CTSN-P, CTSN-B, and CTSN-S are of potent bioactive substances that can be prepared in the cheapest way compared with other molecules tested available for antibacterial agent useful for human oral health. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.subject | ANTIBACTERIAL ACTIVITY | - |
dc.subject | ANTIMICROBIAL ACTIVITY | - |
dc.subject | STAPHYLOCOCCUS-AUREUS | - |
dc.subject | IN-VITRO | - |
dc.subject | CHITOSAN | - |
dc.subject | GROWTH | - |
dc.subject | CHITOOLIGOSACCHARIDES | - |
dc.subject | MECHANISMS | - |
dc.subject | BIOFILMS | - |
dc.subject | XYLITOL | - |
dc.title | Comparison of inhibitory activity of bioactive molecules on the dextransucrase from Streptococcus mutans | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000360087900007 | - |
dc.identifier.doi | 10.1007/s00253-015-6693-z | - |
dc.identifier.bibliographicCitation | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.99, no.18, pp.7495 - 7503 | - |
dc.identifier.scopusid | 2-s2.0-84939572131 | - |
dc.citation.endPage | 7503 | - |
dc.citation.startPage | 7495 | - |
dc.citation.title | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.volume | 99 | - |
dc.citation.number | 18 | - |
dc.contributor.affiliatedAuthor | Lee, Choon Geun | - |
dc.contributor.affiliatedAuthor | Park, Jae Kweon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Dextransucrase | - |
dc.subject.keywordAuthor | Streptococcus mutans | - |
dc.subject.keywordAuthor | Antimicrobial activity | - |
dc.subject.keywordAuthor | Oral health | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordPlus | ANTIBACTERIAL ACTIVITY | - |
dc.subject.keywordPlus | ANTIMICROBIAL ACTIVITY | - |
dc.subject.keywordPlus | STAPHYLOCOCCUS-AUREUS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CHITOOLIGOSACCHARIDES | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | BIOFILMS | - |
dc.subject.keywordPlus | XYLITOL | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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