A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Il Lae | - |
dc.contributor.author | Lee, Ju Hye | - |
dc.contributor.author | Kang, Se Chan | - |
dc.date.available | 2020-02-28T08:43:04Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10210 | - |
dc.description.abstract | It has previously been reported that cold water-extracts of Moringa oleifera leaf have anticancer activity against various human cancer cell lines, including non-small cell lung cancer. In the present study, the anticancer activity of M. oleifera leaf extracts was investigated in human hepatocellular carcinoma HepG2 cells. By the analysis of apoptotic signals, including the induction of caspase or poly(ADP-ribose) polymerase cleavage, and the Annexin V and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assays, it was demonstrated that M. oleifera leaf extracts induce the apoptosis of HepG2 cells. In the hollow fiber assay, oral administration of the leaf extracts significantly reduced (44-52%) the proliferation of the HepG2 cells and A549 non-small cell lung cancer cells. These results support the potential of soluble extracts of M. oleifera leaf as orally administered therapeutics for the treatment of human liver and lung cancers. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.relation.isPartOf | ONCOLOGY LETTERS | - |
dc.subject | ANTIOXIDANT PROPERTIES | - |
dc.subject | IN-VITRO | - |
dc.subject | LAM. | - |
dc.subject | LEAVES | - |
dc.subject | VIRUS | - |
dc.subject | PLANT | - |
dc.subject | THIOCARBAMATE | - |
dc.subject | GLYCOSIDES | - |
dc.subject | PROMOTER | - |
dc.subject | LIVER | - |
dc.title | A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000360923000063 | - |
dc.identifier.doi | 10.3892/ol.2015.3482 | - |
dc.identifier.bibliographicCitation | ONCOLOGY LETTERS, v.10, no.3, pp.1597 - 1604 | - |
dc.identifier.scopusid | 2-s2.0-84937436146 | - |
dc.citation.endPage | 1604 | - |
dc.citation.startPage | 1597 | - |
dc.citation.title | ONCOLOGY LETTERS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kang, Se Chan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Moringa oleifera | - |
dc.subject.keywordAuthor | anticancer drug | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | lung cancer | - |
dc.subject.keywordAuthor | hepatocellular carcinoma cells | - |
dc.subject.keywordPlus | ANTIOXIDANT PROPERTIES | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | LAM. | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | PLANT | - |
dc.subject.keywordPlus | THIOCARBAMATE | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | LIVER | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.