Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface
- Authors
- Lee, Seokwoo; Lee, Yun Mi; Lee, Hyun-Ji; Jeon, Hongjun; Lee, Hyukjin; Shin, Dongyun; Kim, Sanghee
- Issue Date
- Sep-2019
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Ceramide; Click chemistry; Liposomes; Membrane fusion; Triazole
- Citation
- ASIAN JOURNAL OF ORGANIC CHEMISTRY, v.8, no.9, pp.1713 - 1717
- Journal Title
- ASIAN JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 8
- Number
- 9
- Start Page
- 1713
- End Page
- 1717
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1023
- DOI
- 10.1002/ajoc.201900342
- ISSN
- 2193-5807
- Abstract
- An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.
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