The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels
- Authors
- Wie, Jinhong; Kim, Byung Joo; Myeong, Jongyun; Ha, Kotdaji; Jeong, Seung Joo; Yang, Dongki; Kim, Euiyong; Jeon, Ju-Hong; So, Insuk
- Issue Date
- 4-Jul-2015
- Publisher
- TAYLOR & FRANCIS INC
- Citation
- CHANNELS, v.9, no.4, pp.186 - 195
- Journal Title
- CHANNELS
- Volume
- 9
- Number
- 4
- Start Page
- 186
- End Page
- 195
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10318
- DOI
- 10.1080/19336950.2015.1058454
- ISSN
- 1933-6950
- Abstract
- TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic -cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and G(i/o) and G(q) protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.
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Collections - 의과대학 > 의예과 > 1. Journal Articles
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