Predicted EC50 and EC95 of Remifentanil for Smooth Removal of a Laryngeal Mask Airway Under Propofol Anesthesia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Ji Young | - |
dc.contributor.author | Kwak, Hyun Jeong | - |
dc.contributor.author | Lee, Kyung Cheon | - |
dc.contributor.author | Kim, Go Wun | - |
dc.contributor.author | Kim, Jong Yeop | - |
dc.date.available | 2020-02-28T08:45:54Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-07-01 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10344 | - |
dc.description.abstract | Purpose: The purpose of this study was to determine the effect-site concentration (Ce) of remifentanil in 50% of patients (EC50) and 95% of patients (EC95) for smooth laryngeal mask airway (LMA) removal in adults under propofol and remifentanil anesthesia. Materials and Methods: Twenty-five patients of ASA physical status I-II and ages 18-60 years who were to undergo minor gynecological or orthopedic surgery were assessed in this study. Anesthesia was induced and maintained with propofol and remifentanil target-controlled infusion (TCI). Remifentanil was maintained at a predetermined Ce during the emergence period. The modified Dixon's up-and-down method was used to determine the remifentanil concentration, starting from 1.0 ng/mL (step size of 0.2 ng/mL). Successful removal of the LMA was regarded as absence of coughing/gagging, clenched teeth, gross purposeful movements, breath holding, laryngospasm, or desaturation to SpO(2)<90%. Results: The mean +/- SD Ce of remifentanil for smooth LMA removal after propofol anesthesia was 0.83 +/- 0.16 ng/mL. Using isotonic regression with a bootstrapping approach, the estimated EC50 and EC95 of rernifentanil Ce were 0.91 ng/mL [95% confidence interval (CI), 0.77-1.07 ng/mL] and 1.35 ng/mL (95% CI, 1.16-1.38 ng/mL), respectively. Conclusion: Our results showed that remifentanil TCI at an established Ce is a reliable technique for achieving safe and smooth emergence without coughing, laryngospasm, or other airway reflexes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.subject | GENERAL-ANESTHESIA | - |
dc.subject | PREVENTING COUGH | - |
dc.subject | EMERGENCE | - |
dc.subject | DESFLURANE | - |
dc.subject | SEVOFLURANE | - |
dc.subject | INFUSION | - |
dc.subject | SURGERY | - |
dc.subject | CHILDREN | - |
dc.subject | RECOVERY | - |
dc.subject | DESIGN | - |
dc.title | Predicted EC50 and EC95 of Remifentanil for Smooth Removal of a Laryngeal Mask Airway Under Propofol Anesthesia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000356902800033 | - |
dc.identifier.doi | 10.3349/ymj.2015.56.4.1128 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.56, no.4, pp.1128 - 1133 | - |
dc.identifier.kciid | ART002003022 | - |
dc.identifier.scopusid | 2-s2.0-84931047263 | - |
dc.citation.endPage | 1133 | - |
dc.citation.startPage | 1128 | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 56 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Kwak, Hyun Jeong | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Cheon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Laryngeal mask airway | - |
dc.subject.keywordAuthor | effect-site concentration | - |
dc.subject.keywordAuthor | general anesthesia | - |
dc.subject.keywordAuthor | remifentanil | - |
dc.subject.keywordAuthor | target-controlled infusion | - |
dc.subject.keywordAuthor | device removal | - |
dc.subject.keywordPlus | GENERAL-ANESTHESIA | - |
dc.subject.keywordPlus | PREVENTING COUGH | - |
dc.subject.keywordPlus | EMERGENCE | - |
dc.subject.keywordPlus | DESFLURANE | - |
dc.subject.keywordPlus | SEVOFLURANE | - |
dc.subject.keywordPlus | INFUSION | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordPlus | DESIGN | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.