Construction of RNA-Quantum Dot Chimera for Nanoscale Resistive Biomemory Application
- Authors
- Lee, Taek; Yagati, Ajay Kumar; Pi, Fengmei; Sharma, Ashwani; Choi, Jeong-Woo; Guo, Peixuan
- Issue Date
- Jul-2015
- Publisher
- AMER CHEMICAL SOC
- Keywords
- RNA nanotechnology; pRNA-quantum dot chimera; biomolecular electronics; nanoscale resistive biomolecular memory; phi29 DNA packaging motor
- Citation
- ACS NANO, v.9, no.7, pp.6675 - 6682
- Journal Title
- ACS NANO
- Volume
- 9
- Number
- 7
- Start Page
- 6675
- End Page
- 6682
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10381
- DOI
- 10.1021/acsnano.5b03269
- ISSN
- 1936-0851
- Abstract
- RNA nanotechnology offers advantages to construct thermally and chemically stable nanoparticles with well-defined shape and structure. Here we report the development of an RNA-QD (quantum dot) chimera for resistive biomolecular memory application. Each QD holds two copies of the pRNA three-way junction (pRNA-3WJ) of the bacteriophage phi29 DNA packaging motor. The fixed quantity of two RNAs per QD was achieved by immobilizing the pRNA-3WJ with a Sephadex aptamer for resin binding. Two thiolated pRNA-3WJ serve as two feet of the chimera that stand on the gold plate. The RNA nanostructure served as both an insulator and a mediator to provide defined distance between the QD and gold. Immobilization of the chimera nanoparticle was confirmed with scanning tunneling microscopy. As revealed by scanning tunneling spectroscopy, the conjugated pRNA-3WJ-QD chimera exhibited an excellent electrical bistability signal for biomolecular memory function, demonstrating great potential for the development of resistive biomolecular memory and a nano-bio-inspired electronic device for information processing and computing.
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