Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray
DC Field | Value | Language |
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dc.contributor.author | Seo, Hye-Sook | - |
dc.contributor.author | Woo, Jong-Kyu | - |
dc.contributor.author | Shin, Yong Cheol | - |
dc.contributor.author | Ko, Seong-Gyu | - |
dc.date.available | 2020-02-28T08:46:43Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10394 | - |
dc.description.abstract | Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXR agonist, Ro25-7386) were identified using an Affymetrix microarray in normal and malignant breast cells. It was observed that LGD1069, LG100268 and Ro25-7386 suppressed the growth of breast cells. Secondly, several rexinoid-regulated genes were identified, which are involved in cell death, cell growth/maintenance, signal transduction and response to stimulus. These genes may be associated with the growth-suppressive activity of rexinoids. Therefore, the identified genes may serve as biomarkers and novel molecular targets for the prevention and treatment of breast cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.relation.isPartOf | MOLECULAR MEDICINE REPORTS | - |
dc.subject | RETINOIC ACID RECEPTORS | - |
dc.subject | VITAMIN-A | - |
dc.subject | SELECTIVE RETINOIDS | - |
dc.subject | CANCER STATISTICS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | CHEMOPREVENTION | - |
dc.subject | LIGANDS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | ALPHA | - |
dc.title | Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000358134400113 | - |
dc.identifier.doi | 10.3892/mmr.2015.3480 | - |
dc.identifier.bibliographicCitation | MOLECULAR MEDICINE REPORTS, v.12, no.1, pp.800 - 818 | - |
dc.identifier.scopusid | 2-s2.0-84926609075 | - |
dc.citation.endPage | 818 | - |
dc.citation.startPage | 800 | - |
dc.citation.title | MOLECULAR MEDICINE REPORTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Woo, Jong-Kyu | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | rexinoid | - |
dc.subject.keywordAuthor | biomarker | - |
dc.subject.keywordAuthor | LGD1069 | - |
dc.subject.keywordAuthor | LG100268 | - |
dc.subject.keywordAuthor | Ro25-7386 | - |
dc.subject.keywordPlus | RETINOIC ACID RECEPTORS | - |
dc.subject.keywordPlus | VITAMIN-A | - |
dc.subject.keywordPlus | SELECTIVE RETINOIDS | - |
dc.subject.keywordPlus | CANCER STATISTICS | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | CHEMOPREVENTION | - |
dc.subject.keywordPlus | LIGANDS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ALPHA | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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