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New and Facile Synthesis of Aminobicyclo[2.2.1]heptane-2-carboxylic Acids

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dc.contributor.authorKim, Taek-Soo-
dc.contributor.authorSeo, Seung-Yong-
dc.contributor.authorShin, Dongyun-
dc.date.available2020-02-28T09:42:14Z-
dc.date.created2020-02-06-
dc.date.issued2015-06-
dc.identifier.issn0936-5214-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10477-
dc.description.abstractA facile approach for the stereoselective synthesis of a- and b-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid is described. Substrate-controlled -carboxylation of norbonene monoester delivered the asymmetric diester intermediate with high diastereoselectivity (up to 35:1). Sequential chemoselective ester cleavage, Curtius rearrangement, and hydrolysis gave the a- and b-isomers of 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid, respectively.-
dc.language영어-
dc.language.isoen-
dc.publisherGEORG THIEME VERLAG KG-
dc.relation.isPartOfSYNLETT-
dc.subjectALPHA-AMINO-ACIDS-
dc.subjectDIELS-ALDER REACTIONS-
dc.subjectGLUTAMATE-DEHYDROGENASE-
dc.subjectASYMMETRIC-SYNTHESIS-
dc.subject1,2,3,6-TETRAHYDROPYRAZIN-2-ONE STRUCTURE-
dc.subjectSTEREOSELECTIVE-SYNTHESIS-
dc.subjectINSULIN-RELEASE-
dc.subjectBETA-CELL-
dc.subjectDERIVATIVES-
dc.subjectLEUCINE-
dc.titleNew and Facile Synthesis of Aminobicyclo[2.2.1]heptane-2-carboxylic Acids-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000354759100020-
dc.identifier.doi10.1055/s-0034-1378690-
dc.identifier.bibliographicCitationSYNLETT, v.26, no.9, pp.1243 - 1247-
dc.identifier.scopusid2-s2.0-84929703669-
dc.citation.endPage1247-
dc.citation.startPage1243-
dc.citation.titleSYNLETT-
dc.citation.volume26-
dc.citation.number9-
dc.contributor.affiliatedAuthorKim, Taek-Soo-
dc.contributor.affiliatedAuthorSeo, Seung-Yong-
dc.contributor.affiliatedAuthorShin, Dongyun-
dc.type.docTypeArticle-
dc.subject.keywordAuthorcarbocycles-
dc.subject.keywordAuthoramino acids-
dc.subject.keywordAuthorbicyclic compounds-
dc.subject.keywordAuthordiastereoselectivity-
dc.subject.keywordAuthorcarbonylation-
dc.subject.keywordPlusALPHA-AMINO-ACIDS-
dc.subject.keywordPlusDIELS-ALDER REACTIONS-
dc.subject.keywordPlusGLUTAMATE-DEHYDROGENASE-
dc.subject.keywordPlusASYMMETRIC-SYNTHESIS-
dc.subject.keywordPlus1,2,3,6-TETRAHYDROPYRAZIN-2-ONE STRUCTURE-
dc.subject.keywordPlusSTEREOSELECTIVE-SYNTHESIS-
dc.subject.keywordPlusINSULIN-RELEASE-
dc.subject.keywordPlusBETA-CELL-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusLEUCINE-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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