New and Facile Synthesis of Aminobicyclo[2.2.1]heptane-2-carboxylic Acids
DC Field | Value | Language |
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dc.contributor.author | Kim, Taek-Soo | - |
dc.contributor.author | Seo, Seung-Yong | - |
dc.contributor.author | Shin, Dongyun | - |
dc.date.available | 2020-02-28T09:42:14Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 0936-5214 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10477 | - |
dc.description.abstract | A facile approach for the stereoselective synthesis of a- and b-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid is described. Substrate-controlled -carboxylation of norbonene monoester delivered the asymmetric diester intermediate with high diastereoselectivity (up to 35:1). Sequential chemoselective ester cleavage, Curtius rearrangement, and hydrolysis gave the a- and b-isomers of 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid, respectively. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.relation.isPartOf | SYNLETT | - |
dc.subject | ALPHA-AMINO-ACIDS | - |
dc.subject | DIELS-ALDER REACTIONS | - |
dc.subject | GLUTAMATE-DEHYDROGENASE | - |
dc.subject | ASYMMETRIC-SYNTHESIS | - |
dc.subject | 1,2,3,6-TETRAHYDROPYRAZIN-2-ONE STRUCTURE | - |
dc.subject | STEREOSELECTIVE-SYNTHESIS | - |
dc.subject | INSULIN-RELEASE | - |
dc.subject | BETA-CELL | - |
dc.subject | DERIVATIVES | - |
dc.subject | LEUCINE | - |
dc.title | New and Facile Synthesis of Aminobicyclo[2.2.1]heptane-2-carboxylic Acids | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000354759100020 | - |
dc.identifier.doi | 10.1055/s-0034-1378690 | - |
dc.identifier.bibliographicCitation | SYNLETT, v.26, no.9, pp.1243 - 1247 | - |
dc.identifier.scopusid | 2-s2.0-84929703669 | - |
dc.citation.endPage | 1247 | - |
dc.citation.startPage | 1243 | - |
dc.citation.title | SYNLETT | - |
dc.citation.volume | 26 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Kim, Taek-Soo | - |
dc.contributor.affiliatedAuthor | Seo, Seung-Yong | - |
dc.contributor.affiliatedAuthor | Shin, Dongyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | carbocycles | - |
dc.subject.keywordAuthor | amino acids | - |
dc.subject.keywordAuthor | bicyclic compounds | - |
dc.subject.keywordAuthor | diastereoselectivity | - |
dc.subject.keywordAuthor | carbonylation | - |
dc.subject.keywordPlus | ALPHA-AMINO-ACIDS | - |
dc.subject.keywordPlus | DIELS-ALDER REACTIONS | - |
dc.subject.keywordPlus | GLUTAMATE-DEHYDROGENASE | - |
dc.subject.keywordPlus | ASYMMETRIC-SYNTHESIS | - |
dc.subject.keywordPlus | 1,2,3,6-TETRAHYDROPYRAZIN-2-ONE STRUCTURE | - |
dc.subject.keywordPlus | STEREOSELECTIVE-SYNTHESIS | - |
dc.subject.keywordPlus | INSULIN-RELEASE | - |
dc.subject.keywordPlus | BETA-CELL | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | LEUCINE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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