Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC/Nga murine model of atopic dermatitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Bo-Kyung | - |
dc.contributor.author | Park, Yang-Chun | - |
dc.contributor.author | Jung, In Chul | - |
dc.contributor.author | Kim, Seung-Hyung | - |
dc.contributor.author | Choi, Jeong June | - |
dc.contributor.author | Do, Moonho | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Jin, Mirim | - |
dc.date.available | 2020-02-28T09:43:12Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-05-13 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10530 | - |
dc.description.abstract | Ethnopharmacological relevance: Gamisasangja-tang (GST) is a traditional herbal formula prescribed for patients with intractable pruritus in association with various inflammatory skin diseases. To evaluate the effects of GST on pruritic skin inflammation and investigate its cellular and molecular mechanisms. Materials and methods: We orally administered GST to NC/Nga (NC) mice, an animal model of atopic dermatitis. Scratching frequency and the dermatitis index were evaluated, and histological examination was performed using hematoxylin and eosin and toluidine blue staining. The levels of interleukin (IL)-31 and T-helper cell type 2 (T(H)2) cytokines were determined in both the dorsal skin and cultured splenocytes by real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The serum levels of chemokines and immunoglobulin E (IgE) were determined by ELISA. Changes in the inflammatory cell population were analyzed by a hemocytometer. Results: GST significantly lowered scratching frequency and inhibited increases in dermatitis index, thickness of epidermis/dermis and infiltration of chemokine (C-C motif) receptor 3 (CCR3)(+) and cluster of differentiation (CD)117(+)/Fc epsilon RI alpha (Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide)(+) cells in atopic skin. Both IL-31 mRNA expression and production were significantly reduced by GST, which was accomrease in the levels of IL-4, IL-5, and IL-13. Further, GST treatment suppressed the secretion of eotaxin, TARC (thymus and activation-regulated chemokine), IgE, and increases in the number of basophils and eosinophils in the blood. Conclusion: GST may have potential as an effective treatment for pruritic skin disease such as atopic dermatitis. (C) 2015 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.relation.isPartOf | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.subject | CNIDIUM-MONNIERI | - |
dc.subject | T-CELLS | - |
dc.subject | IN-VITRO | - |
dc.subject | IL-31 | - |
dc.subject | MICE | - |
dc.subject | JAPONICA | - |
dc.subject | PATHOPHYSIOLOGY | - |
dc.subject | EXPRESSION | - |
dc.subject | FLAVONOIDS | - |
dc.subject | CHEMOKINES | - |
dc.title | Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC/Nga murine model of atopic dermatitis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000353602700007 | - |
dc.identifier.doi | 10.1016/j.jep.2015.02.040 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ETHNOPHARMACOLOGY, v.165, pp.54 - 60 | - |
dc.identifier.scopusid | 2-s2.0-84924273080 | - |
dc.citation.endPage | 60 | - |
dc.citation.startPage | 54 | - |
dc.citation.title | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.volume | 165 | - |
dc.contributor.affiliatedAuthor | Do, Moonho | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Gamisasangja-tang (GST) | - |
dc.subject.keywordAuthor | Pruritus | - |
dc.subject.keywordAuthor | Atopic skin inflammation | - |
dc.subject.keywordAuthor | IL-31 | - |
dc.subject.keywordAuthor | NC/Nga murine model | - |
dc.subject.keywordPlus | CNIDIUM-MONNIERI | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | IL-31 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | JAPONICA | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | CHEMOKINES | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.