SG-HQ2 inhibits mast cell-mediated allergic inflammation through suppression of histamine release and pro-inflammatory cytokines
DC Field | Value | Language |
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dc.contributor.author | Je, In-Gyu | - |
dc.contributor.author | Kim, Hui-Hun | - |
dc.contributor.author | Park, Pil-Hoon | - |
dc.contributor.author | Kwon, Taeg Kyu | - |
dc.contributor.author | Seo, Seung-Yong | - |
dc.contributor.author | Shin, Tae-Yong | - |
dc.contributor.author | Kim, Sang-Hyun | - |
dc.date.available | 2020-02-28T09:44:04Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 1535-3702 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10584 | - |
dc.description.abstract | In this study, we investigated the effect of 3,4,5-trihydroxy-N-(8-hydroxyquinolin-2-yl)benzamide) (SG-HQ2), a synthetic analogue of gallic acid (3,4,5-trihydroxybenzoic acid), on the mast cell-mediated allergic inflammation and the possible mechanism of action. Mast cells play major roles in immunoglobulin E-mediated allergic responses by the release of histamine, lipid-derived mediators, and pro-inflammatory cytokines. We previously reported the potential effects of gallic acid using allergic inflammation models. For incremental research, we synthesized the SG-HQ2 by the modification of functional groups from gallic acid. SG-HQ2 attenuated histamine release by the reduction of intracellular calcium in human mast cells and primary peritoneal mast cells. The inhibitory efficacy of SG-HQ2 was similar with gallic acid. Enhanced expression of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1 beta, interleukin-4, and interleukin-6 in activated mast cells was significantly diminished by SG-HQ2 100 times lower concentration of gallic acid. This inhibitory effect was mediated by the reduction of nuclear factor-kappa B. In animal models, SG-HQ2 inhibited compound 48/80-induced serum histamine release and immunoglobulin E-mediated local allergic reaction, passive cutaneous anaphylaxis. Our results indicate that SG-HQ2, an analogue of gallic acid, might be a possible therapeutic candidate for mast cell-mediated allergic inflammatory diseases through suppression of histamine release and pro-inflammatory cytokines. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.relation.isPartOf | EXPERIMENTAL BIOLOGY AND MEDICINE | - |
dc.subject | PASSIVE CUTANEOUS ANAPHYLAXIS | - |
dc.subject | CALCIUM | - |
dc.subject | IL-6 | - |
dc.subject | EPIGALLOCATECHIN-3-GALLATE | - |
dc.subject | INNATE | - |
dc.subject | IGE | - |
dc.title | SG-HQ2 inhibits mast cell-mediated allergic inflammation through suppression of histamine release and pro-inflammatory cytokines | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000354325700011 | - |
dc.identifier.doi | 10.1177/1535370214555663 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL BIOLOGY AND MEDICINE, v.240, no.5, pp.631 - 638 | - |
dc.identifier.scopusid | 2-s2.0-84930436938 | - |
dc.citation.endPage | 638 | - |
dc.citation.startPage | 631 | - |
dc.citation.title | EXPERIMENTAL BIOLOGY AND MEDICINE | - |
dc.citation.volume | 240 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Seo, Seung-Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Allergic inflammation | - |
dc.subject.keywordAuthor | mast cells | - |
dc.subject.keywordAuthor | histamine | - |
dc.subject.keywordAuthor | pro-inflammatory cytokine | - |
dc.subject.keywordPlus | PASSIVE CUTANEOUS ANAPHYLAXIS | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | IL-6 | - |
dc.subject.keywordPlus | EPIGALLOCATECHIN-3-GALLATE | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | IGE | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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