Lignan Glycosides from the Twigs of Chaenomeles sinensis and Their Biological Activities
DC Field | Value | Language |
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dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Subedi, Lalita | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T09:44:11Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10589 | - |
dc.description.abstract | Phytochemical investigation of the twigs of Chaenomeles sinensis led to the isolation and identification of six new lignan glycosides, chaenomiside A-F (1-6), along with five known ones (7-11). Their chemical structures were determined by spectroscopic methods, including NMR, MS, ECD, and GC/MS analyses. All the isolated compounds (1-11) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-activated murine microglial cells and the secretion of nerve growth factor (NGF) in a C6 rat glioma cell line. Compound 6 significantly reduced NO levels in the murine microglia BV2 cells with an IC50 value of 21.3 mu M, and compounds 1, 3, and 6 were potent stimulants of NGF release with stimulation levels of 151.74 +/- 6.77%, 144.31 +/- 7.49%, and 167.61 +/- 18.5%, respectively. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.subject | FRUITS | - |
dc.subject | CONSTITUENTS | - |
dc.subject | DERIVATIVES | - |
dc.subject | FLAVONOIDS | - |
dc.subject | EXTRACT | - |
dc.subject | LEAVES | - |
dc.title | Lignan Glycosides from the Twigs of Chaenomeles sinensis and Their Biological Activities | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000355158300025 | - |
dc.identifier.doi | 10.1021/acs.jnatprod.5b00090 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.78, no.5, pp.1174 - 1178 | - |
dc.identifier.scopusid | 2-s2.0-84930208066 | - |
dc.citation.endPage | 1178 | - |
dc.citation.startPage | 1174 | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 78 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Subedi, Lalita | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FRUITS | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | LEAVES | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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