Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish
DC Field | Value | Language |
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dc.contributor.author | Lee, Ik-Soo | - |
dc.contributor.author | Kim, Young Sook | - |
dc.contributor.author | Jung, Seung-Hyun | - |
dc.contributor.author | Yu, Song Yi | - |
dc.contributor.author | Kim, Joo-Hwan | - |
dc.contributor.author | Sun, Hang | - |
dc.contributor.author | Kim, Jin Sook | - |
dc.date.available | 2020-02-28T09:44:33Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-04-03 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10599 | - |
dc.description.abstract | In our continuing search for novel antiangiogenic agents, a new lignan glycoside, (7R,8R)-1-(4-O-beta-d-glucopyranosyl-3-methoxyphenyl)-2-{2-methoxy-4-[1-(E)-propene-3-ol]-phenoxyl}-propane-1,3-diol (1), along with three known lignans (2-4), were isolated from the 80% EtOH extract of Brandisia hancei stems and leaves. These isolates (1-4) were subjected to an in vitro bioassay to evaluate their effects on vascular endothelial growth factor (VEGF)-induced vascular permeability and migration of human retinal endothelial cells (HRECs). Of the compounds tested, compound 1 resulted in the greatest reduction in VEGF-induced vascular permeability by about 31.5% at 10 mu M compared to the VEGF-treated control. In the migration assay, compounds 1 and 2 significantly decreased VEGF-induced HREC migration. Furthermore, zebrafish embryos treated with compounds 1 and 2 showed mild reductions of dorsal longitudinal anastomotic vessel (DLAV) formation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | PHENYLETHANOIDS | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | NEOLIGNANS | - |
dc.subject | ACTEOSIDE | - |
dc.title | Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000353479000008 | - |
dc.identifier.doi | 10.1080/09168451.2014.991687 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.79, no.4, pp.581 - 586 | - |
dc.identifier.scopusid | 2-s2.0-84927637998 | - |
dc.citation.endPage | 586 | - |
dc.citation.startPage | 581 | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 79 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Kim, Joo-Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | lignans | - |
dc.subject.keywordAuthor | Scrophulariaceae | - |
dc.subject.keywordAuthor | vascular endothelial growth factor | - |
dc.subject.keywordAuthor | zebrafish | - |
dc.subject.keywordAuthor | Brandisia hancei | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | PHENYLETHANOIDS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | NEOLIGNANS | - |
dc.subject.keywordPlus | ACTEOSIDE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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