Liposomal co-delivery of curcumin and albumin/paclitaxel nanoparticle for enhanced synergistic antitumor efficacy
DC Field | Value | Language |
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dc.contributor.author | Ruttala, Hima Bindu | - |
dc.contributor.author | Ko, Young Tag | - |
dc.date.available | 2020-02-28T09:44:43Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-04-01 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10609 | - |
dc.description.abstract | Paclitaxel (PTX) and curcumin (CUR) are potent chemotherapeutic agents used in the treatment of cancer. In the present study, hybrid polymer-lipid nanoparticles co-loaded with PTX and CUR were developed to investigate the therapeutic potential of a combination drug regimen. For this purpose, PTX-loaded albumin nanoparticles (APN) were prepared and encapsulated in PEGylated hybrid liposomes containing CUR (CL-APN) via a thin-film hydration technique. CL-APN was nanosized with a uniform spherical morphology. PTX and CUR release was sustained and occurred in a sequential manner, wherein CUR was expected to downregulate the nuclear factor NF-kappa B and Akt pathways and increase the therapeutic efficacy of PTX. The ratiometric combination of PTX and CUR was significantly more cytotoxic than the individual drugs. Importantly, dual-drug-loaded nanocarriers exhibited a superior cytotoxic effect than a cocktail combination at a lower dose. CL-APN induced significantly higher early and late apoptosis, induced a stronger G(2)/M arrest, and significantly increased the subG(1) cell population. By combining CUR, an effective NF-kappa B inhibitor, with PTX, a powerful anticancer drug, in a polymer-lipid hybrid nanoparticle system, we could improve the therapeutic efficacy in cancer treatments. Our results showed that such co-loaded delivery systems could serve as a promising therapeutic approach to improve clinical outcomes against various malignancies. (C) 2015 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.subject | KAPPA-B ACTIVATION | - |
dc.subject | CHEMOTHERAPEUTIC RESPONSE | - |
dc.subject | MULTIDRUG-RESISTANCE | - |
dc.subject | POLYMERIC MICELLES | - |
dc.subject | COMPLEX MICELLES | - |
dc.subject | RNA EXPRESSION | - |
dc.subject | BREAST-CANCER | - |
dc.subject | DRUGS | - |
dc.subject | PROLIFERATION | - |
dc.subject | GLYCOPROTEIN | - |
dc.title | Liposomal co-delivery of curcumin and albumin/paclitaxel nanoparticle for enhanced synergistic antitumor efficacy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000353930000053 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2015.02.040 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.128, pp.419 - 426 | - |
dc.identifier.scopusid | 2-s2.0-84928734444 | - |
dc.citation.endPage | 426 | - |
dc.citation.startPage | 419 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 128 | - |
dc.contributor.affiliatedAuthor | Ruttala, Hima Bindu | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Curcumin | - |
dc.subject.keywordAuthor | Albumin PTX nanoparticle | - |
dc.subject.keywordAuthor | Liposome | - |
dc.subject.keywordAuthor | Synergism | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | CHEMOTHERAPEUTIC RESPONSE | - |
dc.subject.keywordPlus | MULTIDRUG-RESISTANCE | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | COMPLEX MICELLES | - |
dc.subject.keywordPlus | RNA EXPRESSION | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | GLYCOPROTEIN | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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