Proteomic Analysis of Serum from Patients with Major Depressive Disorder to Compare Their Depressive and Remission Statuses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jiyeong | - |
dc.contributor.author | Joo, Eun-Jeong | - |
dc.contributor.author | Lim, Hee-Joung | - |
dc.contributor.author | Park, Jong-Moon | - |
dc.contributor.author | Lee, Kyu Young | - |
dc.contributor.author | Park, Arum | - |
dc.contributor.author | Seok, AeEun | - |
dc.contributor.author | Lee, HooKeun | - |
dc.contributor.author | Kang, Hee-Gyoo | - |
dc.date.available | 2020-02-28T09:44:54Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10615 | - |
dc.description.abstract | Objective Currently, there are a few biological markers to aid in the diagnosis and treatment of depression. However, it is not sufficient for diagnosis. We attempted to identify differentially expressed proteins during depressive moods as putative diagnostic biomarkers by using quantitative proteomic analysis of serum. Methods Blood samples were collected twice from five patients with major depressive disorder (MDD) at depressive status before treatment and at remission status during treatment. Samples were individually analyzed by liquid chromatography-tandem mass spectrometry for protein profiling. Differentially expressed proteins were analyzed by label-free quantification. Enzyme-linked immunosorbent assay (ELISA) results and receiver-operating characteristic (ROC) curves were used to validate the differentially expressed proteins. For validation, 8 patients with MDD including 3 additional patients and 8 matched normal controls were analyzed. Results The quantitative proteomic studies identified 10 proteins that were consistently upregulated or downregulated in 5 MDD patients. ELISA yielded results consistent with the proteomic analysis for 3 proteins. Expression levels were significantly different between normal controls and MDD patients. The 3 proteins were ceruloplasmin, inter-alpha-trypsin inhibitor heavy chain H4 and complement component 1qC, which were upregulated during the depressive status. The depressive status could be distinguished from the euthymic status from the ROC curves for these proteins, and this discrimination was enhanced when all 3 proteins were analyzed together. Conclusion This is the first proteomic study in MDD patients to compare intra-individual differences dependent on mood. This technique could be a useful approach to identify MDD biomarkers, but requires additional proteomic studies for validation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NEUROPSYCHIATRIC ASSOC | - |
dc.relation.isPartOf | PSYCHIATRY INVESTIGATION | - |
dc.subject | ACUTE-PHASE PROTEINS | - |
dc.subject | STIMULATING-HORMONE | - |
dc.subject | NEUROTROPHIC FACTOR | - |
dc.subject | FOLLOW-UP | - |
dc.subject | PLASMA | - |
dc.subject | IDENTIFICATION | - |
dc.subject | SCHIZOPHRENIA | - |
dc.subject | CERULOPLASMIN | - |
dc.subject | BIOMARKERS | - |
dc.subject | CORTEX | - |
dc.title | Proteomic Analysis of Serum from Patients with Major Depressive Disorder to Compare Their Depressive and Remission Statuses | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000353367600014 | - |
dc.identifier.doi | 10.4306/pi.2015.12.2.249 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, v.12, no.2, pp.249 - 259 | - |
dc.identifier.kciid | ART002015786 | - |
dc.identifier.scopusid | 2-s2.0-84928266711 | - |
dc.citation.endPage | 259 | - |
dc.citation.startPage | 249 | - |
dc.citation.title | PSYCHIATRY INVESTIGATION | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Park, Jong-Moon | - |
dc.contributor.affiliatedAuthor | Lee, HooKeun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Major depressive disorder | - |
dc.subject.keywordAuthor | Neurotransmitter | - |
dc.subject.keywordAuthor | Proteomics | - |
dc.subject.keywordPlus | ACUTE-PHASE PROTEINS | - |
dc.subject.keywordPlus | STIMULATING-HORMONE | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | CERULOPLASMIN | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | CORTEX | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.