Metabolomic identification of biochemical changes induced by fluoxetine and imipramine in a chronic mild stress mouse model of depression
DC Field | Value | Language |
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dc.contributor.author | Zhao, Jing | - |
dc.contributor.author | Jung, Yang-Hee | - |
dc.contributor.author | Jang, Choon-Gon | - |
dc.contributor.author | Chun, Kwang-Hoon | - |
dc.contributor.author | Kwon, Sung Won | - |
dc.contributor.author | Lee, Jeongmi | - |
dc.date.available | 2020-02-28T09:46:14Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-03-09 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10682 | - |
dc.description.abstract | Metabolomics was applied to a C57BL/6N mouse model of chronic unpredictable mild stress (CMS). Such mice were treated with two antidepressants from different categories: fluoxetine and imipramine. Metabolic profiling of the hippocampus was performed using gas chromatography-mass spectrometry analysis on samples prepared under optimized conditions, followed by principal component analysis, partial least squares-discriminant analysis, and pair-wise orthogonal projections to latent structures discriminant analyses. Body weight measurement and behavior tests including an open field test and the forced swimming test were completed with the mice as a measure of the phenotypes of depression and antidepressive effects. As a result, 23 metabolites that had been differentially expressed among the control, CMS, and antidepressant-treated groups demonstrated that amino acid metabolism, energy metabolism, adenosine receptors, and neurotransmitters are commonly perturbed by drug treatment. Potential predictive markers for treatment effect were identified: myo-inositol for fluoxetine and lysine and oleic acid for imipramine. Collectively, the current study provides insights into the molecular mechanisms of the antidepressant effects of two widely used medications. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.subject | ANIMAL-MODELS | - |
dc.subject | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject | RAT MODEL | - |
dc.subject | SEROTONIN | - |
dc.subject | ANTIDEPRESSANTS | - |
dc.subject | METABONOMICS | - |
dc.subject | GLUTAMATE | - |
dc.subject | REVEALS | - |
dc.subject | ANXIETY | - |
dc.subject | MICE | - |
dc.title | Metabolomic identification of biochemical changes induced by fluoxetine and imipramine in a chronic mild stress mouse model of depression | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000350550600004 | - |
dc.identifier.doi | 10.1038/srep08890 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.5 | - |
dc.identifier.scopusid | 2-s2.0-84924405218 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Chun, Kwang-Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ANIMAL-MODELS | - |
dc.subject.keywordPlus | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject.keywordPlus | RAT MODEL | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | ANTIDEPRESSANTS | - |
dc.subject.keywordPlus | METABONOMICS | - |
dc.subject.keywordPlus | GLUTAMATE | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | ANXIETY | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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