Anti-Obesity Effects of the Flower of Prunus persica in High-Fat Diet-Induced Obese Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Jungbin | - |
dc.contributor.author | Kim, Young-Sik | - |
dc.contributor.author | Kim, Linae | - |
dc.contributor.author | Park, Hyo Jin | - |
dc.contributor.author | Lee, Donghun | - |
dc.contributor.author | Kim, Hocheol | - |
dc.date.available | 2020-02-27T02:22:48Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1070 | - |
dc.description.abstract | Prunus persica (L.) Batsch is a deciduous fruit tree cultivated worldwide. The flower of P. persica (PPF), commonly called the peach blossom, is currently consumed as a tea for weight loss in East Asia; however, its anti-obesity effects have yet to be demonstrated in vitro or in vivo. Since PPF is rich in phytochemicals with anti-obesity properties, we aimed to investigate the effects of PPF on obesity and its underlying mechanism using a diet-induced obesity model. Male C57BL/6 mice were fed either normal diet, high-fat diet (HFD), or HFD containing 0.2% or 0.6% PPF water extract for 8 weeks. PPF significantly reduced body weight, abdominal fat mass, serum glucose, alanine transaminase and aspartate aminotransferase levels, and liver and spleen weights compared to the HFD control group. Real-time quantitative polymerase chain reaction analysis revealed that PPF suppressed lipogenic gene expression, including stearoyl-CoA desaturase-1 and -2 and fatty acid synthase, and up-regulated the fatty acid beta-oxidation gene, carnitine palmitoyltransferase-1, in the liver. Our results suggest that PPF exerts anti-obesity effects in obese mice and these beneficial effects might be mediated through improved hepatic lipid metabolism by reducing lipogenesis and increasing fatty acid oxidation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.subject | WHITE ADIPOSE-TISSUE | - |
dc.subject | STEAROYL-COA | - |
dc.subject | LIVER | - |
dc.subject | INFLAMMATION | - |
dc.subject | CONSTITUENTS | - |
dc.subject | DEFICIENCY | - |
dc.subject | EXPRESSION | - |
dc.subject | LIPOLYSIS | - |
dc.subject | PROTECTS | - |
dc.subject | EXTRACT | - |
dc.title | Anti-Obesity Effects of the Flower of Prunus persica in High-Fat Diet-Induced Obese Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000487964600244 | - |
dc.identifier.doi | 10.3390/nu11092176 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.11, no.9 | - |
dc.identifier.scopusid | 2-s2.0-85072149239 | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Lee, Donghun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Prunus persica | - |
dc.subject.keywordAuthor | peach blossom | - |
dc.subject.keywordAuthor | high-fat diet | - |
dc.subject.keywordAuthor | anti-obesity | - |
dc.subject.keywordAuthor | glucose | - |
dc.subject.keywordAuthor | liver | - |
dc.subject.keywordAuthor | lipogenesis | - |
dc.subject.keywordAuthor | beta-oxidation | - |
dc.subject.keywordPlus | WHITE ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | STEAROYL-COA | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | DEFICIENCY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LIPOLYSIS | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.