Protective Effect of Tetrahydrocurcumin against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies
DC Field | Value | Language |
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dc.contributor.author | Song, Kyung Il | - |
dc.contributor.author | Park, Jun Yeon | - |
dc.contributor.author | Lee, Seungyong | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Jang, Hyuk-Jai | - |
dc.contributor.author | Kim, Su-Nam | - |
dc.contributor.author | Ko, Hyeonseok | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Lee, JaeWook | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Yamabe, Noriko | - |
dc.date.available | 2020-02-28T09:47:02Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10718 | - |
dc.description.abstract | The adverse effects of anticancer drugs can prompt patients to end their treatment despite the efficacy. Cisplatin is a platinum-based molecule widely used to treat various forms of cancer, but frequent and long-term use of cisplatin is limited due to severe nephrotoxicity. In the present study, we investigated the protective effect and mechanism of tetrahydrocurcumin on cisplatin-induced kidney damage, oxidative stress, and inflammation to evaluate its possible use in renal damage. Cisplatin-induced LLC-PK1 renal cell damage was significantly reduced by tetrahydrocurcumin treatment. Additionally, the protective effect of tetrahydrocurcumin on cisplatin-induced oxidative renal damage was investigated in rats. Tetrahydrocurcumin was orally administered every day at a dose of 80 mg/kg body weight for ten days, and a single dose of cisplatin was administered intraperitoneally (7.5 mg/kg body weight) in 0.9% saline on day four. The creatinine clearance levels, which were markers of renal dysfunction, in cisplatin-treated rats were recovered nearly back to normal levels after administration of tetrahydrocurcumin. Moreover, tetrahydrocurcumin exhibited protective effects against cisplatin-induced oxidative renal damage in rats by inhibiting cyclooxygenase-2 and caspase-3 activation. These results collectively provide therapeutic evidence that tetrahydrocurcumin ameliorates renal damage by regulating inflammation and apoptosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.relation.isPartOf | PLANTA MEDICA | - |
dc.subject | GINSENOSIDE RE | - |
dc.subject | MAILLARD REACTION | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | MOUSE EPIDERMIS | - |
dc.subject | NEPHROTOXICITY | - |
dc.subject | CURCUMIN | - |
dc.subject | ANTICANCER | - |
dc.subject | CELLS | - |
dc.subject | MECHANISMS | - |
dc.subject | CARCINOMA | - |
dc.title | Protective Effect of Tetrahydrocurcumin against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000350747900004 | - |
dc.identifier.doi | 10.1055/s-0035-1545696 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.81, no.4, pp.286 - 291 | - |
dc.identifier.scopusid | 2-s2.0-84925465271 | - |
dc.citation.endPage | 291 | - |
dc.citation.startPage | 286 | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 81 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Park, Jun Yeon | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.contributor.affiliatedAuthor | Yamabe, Noriko | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | cisplatin | - |
dc.subject.keywordAuthor | nephrotoxicity | - |
dc.subject.keywordAuthor | tetrahydrocurcumin | - |
dc.subject.keywordAuthor | oxidative renal damage | - |
dc.subject.keywordAuthor | COX-2 | - |
dc.subject.keywordPlus | GINSENOSIDE RE | - |
dc.subject.keywordPlus | MAILLARD REACTION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MOUSE EPIDERMIS | - |
dc.subject.keywordPlus | NEPHROTOXICITY | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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