Pentacyclic Antibiotics from a Tidal Mud Flat-Derived Actinomycete
DC Field | Value | Language |
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dc.contributor.author | Moon, Kyuho | - |
dc.contributor.author | Chung, Beomkoo | - |
dc.contributor.author | Shin, Yoonho | - |
dc.contributor.author | Rheingold, Arnold L. | - |
dc.contributor.author | Moore, Curtis E. | - |
dc.contributor.author | Park, Sung Jean | - |
dc.contributor.author | Park, Sunghyouk | - |
dc.contributor.author | Lee, Sang Kook | - |
dc.contributor.author | Oh, Ki-Bong | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.date.available | 2020-02-28T09:47:07Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10721 | - |
dc.description.abstract | The combination of investigating a unique source of chemically prolific bacterium with an LC/MS-based bacterial strain selection approach resulted in the discovery of two new secondary metabolites, buanmycin (1) and buanquinone (2), from the culture of a marine Streptomyces strain, which was isolated from a tidal mudflat in Buan, Republic of Korea. The carbon backbone of buanmycin (1), comprising 20 quaternary carbons out of 30 total carbons, was determined via C-13-C-13 COSY NMR analysis after labeling 1 with C-13 by culturing the bacterium with C-13-glucose. The complete structure of 1 was confidently elucidated, primarily based on 1D and 2D NMR spectroscopic and X-ray crystallographic analysis, as that of a new pentacyclic xanthone. The absolute configuration of the a-methyl serine unit in 1 was established by applying the advanced Marfey's method. The structure of buanquinone (2) was determined to be a new pentacyclic quinone based on NMR and MS spectroscopic data. Buanmycin exhibited potent cytotoxicity against colorectal carcinoma cells (HCT-116) and gastric carcinoma cells (SNU-638) with submicromolar IC50 values and strongly inhibited the pathogenic Gram-negative bacterium Salmonella enterica (MIC = 0.7 mu M). In particular, buanmycin demonstrated inhibition of sortase A, which is a promising target for antibiotic discovery. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.subject | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | - |
dc.subject | CONSTITUENT AMINO-ACIDS | - |
dc.subject | ABSOLUTE-CONFIGURATION | - |
dc.subject | MASS-SPECTROMETRY | - |
dc.subject | MARFEYS METHOD | - |
dc.subject | DISCOVERY | - |
dc.subject | PEPTIDE | - |
dc.subject | INHIBITOR | - |
dc.subject | SORTASE | - |
dc.subject | SURFACE | - |
dc.title | Pentacyclic Antibiotics from a Tidal Mud Flat-Derived Actinomycete | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000352033900023 | - |
dc.identifier.doi | 10.1021/np500736b | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.78, no.3, pp.524 - 529 | - |
dc.identifier.scopusid | 2-s2.0-84925953537 | - |
dc.citation.endPage | 529 | - |
dc.citation.startPage | 524 | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 78 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Park, Sung Jean | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | - |
dc.subject.keywordPlus | CONSTITUENT AMINO-ACIDS | - |
dc.subject.keywordPlus | ABSOLUTE-CONFIGURATION | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | MARFEYS METHOD | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | SORTASE | - |
dc.subject.keywordPlus | SURFACE | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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