Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun-Bum | - |
dc.contributor.author | Kwon, Byeong-Jae | - |
dc.contributor.author | Cho, Hyun-Ji | - |
dc.contributor.author | Kim, Ji-Won | - |
dc.contributor.author | Chon, Jeong-Woo | - |
dc.contributor.author | Do, Moon-Ho | - |
dc.contributor.author | Park, Sang-Yong | - |
dc.contributor.author | Kim, Sun-Yeou | - |
dc.contributor.author | Maeng, Sung-Ho | - |
dc.contributor.author | Park, Yoo-Kyoung | - |
dc.contributor.author | Park, Ji-Ho | - |
dc.date.available | 2020-02-28T10:41:16Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10730 | - |
dc.description.abstract | Artemisia princeps (AP) is a flowering perennial used as a traditional medicine and dietary supplement across East Asia. No study has yet assessed its effects on synaptic plasticity in hippocampus and much less in a model of ovarian hormone deficiency. We examined the influence of chronic oral AP ethanol extract treatment in ovariectomized rats on the induction of long-term depression in a representative synapse (CA3-CA1) of the hippocampus. Ovariectomized rats demonstrated lower trabecular mean bone mineral densities than sham, validating the establishment of pathology. Against this background of pathology, AP-treated ovariectomized rats exhibited attenuated long-term depression (LTD) in CA1 relative to water-treated controls as measured by increased field excitatory post-synaptic potentials (fEPSP) activation averages over the post-stimulation period. While pathological significance of long-term depression (LTD) in ovariectomized rats is conflicting, that AP treatment significantly affected its induction offers justification for further study of its influences on plasticity and its related disorders. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE | - |
dc.relation.isPartOf | EXPERIMENTAL NEUROBIOLOGY | - |
dc.title | Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.wosid | 000218572700008 | - |
dc.identifier.doi | 10.5607/en.2015.24.1.71 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL NEUROBIOLOGY, v.24, no.1, pp.71 - 83 | - |
dc.identifier.kciid | ART001981424 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 83 | - |
dc.citation.startPage | 71 | - |
dc.citation.title | EXPERIMENTAL NEUROBIOLOGY | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Do, Moon-Ho | - |
dc.contributor.affiliatedAuthor | Kim, Sun-Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Artemisia princeps | - |
dc.subject.keywordAuthor | Oriental medicine | - |
dc.subject.keywordAuthor | ovariectomy | - |
dc.subject.keywordAuthor | long-term depression ( LTD) | - |
dc.subject.keywordAuthor | hippocampal synaptic plasticity | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | kci | - |
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