The factors associated with longitudinal changes in liver stiffness in patients with chronic hepatitis B
DC Field | Value | Language |
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dc.contributor.author | Yo, In Ku | - |
dc.contributor.author | Kwon, Oh Sang | - |
dc.contributor.author | Park, Jin Woong | - |
dc.contributor.author | Lee, Jong Joon | - |
dc.contributor.author | Lee, Jung Hyun | - |
dc.contributor.author | Won, In Sik | - |
dc.contributor.author | Na, Sun Young | - |
dc.contributor.author | Jang, Pil Kyu | - |
dc.contributor.author | Park, Pyung Hwa | - |
dc.contributor.author | Choi, Duck Joo | - |
dc.contributor.author | Kim, Yun Soo | - |
dc.contributor.author | Kim, Ju Hyun | - |
dc.date.available | 2020-02-28T10:41:24Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 2287-2728 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10738 | - |
dc.description.abstract | Background/Aims: Liver stiffness (LS) as assessed by transient elastography (TE) can change longitudinally in patients with chronic hepatitis B (CHB). The aim of this study was to identify the factors that improve LS. Methods: Between April 2007 and December 2012, 151 patients with CHB who underwent two TE procedures with an interval of about 2 years were enrolled. Ninety-six of the 151 patients were treated with nucleos(t) ide analogues [the antiviral therapy (+) group], while the remaining 55 patients were not [the antiviral therapy (-) group]. The two groups of patients were stratified according to whether they exhibited an improvement or a deterioration in LS during the study period (defined as an LS change of <= 0 or >0 kPa, respectively, over a 1-year period), and their data were compared. Results: No differences were observed between the antiviral therapy (+) and (-) groups with respect to either their clinical characteristics or their initial LS. The observed LS improvement was significantly greater in the antiviral therapy (+) group than in the antiviral therapy (-) group (-3.0 vs. 0.98 kPa, P=0.011). In the antiviral therapy (+) group, the initial LS was higher in the LS improvement group (n=63) than in the LS deterioration group (n=33; 7.9 vs. 4.8 kPa, P<0.001). However, there were no differences in any other clinical characteristic. In the antiviral therapy (-) group, the initial LS was also higher in the LS improvement group (n=29) than in the LS deterioration group (n=26; 8.3 vs. 6.5 kPa, P=0.021), with no differences in any other clinical characteristic. Conclusions: A higher initial LS was the only factor associated with LS improvement in patients with CHB in this study. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC STUDY LIVER | - |
dc.relation.isPartOf | CLINICAL AND MOLECULAR HEPATOLOGY | - |
dc.title | The factors associated with longitudinal changes in liver stiffness in patients with chronic hepatitis B | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000409422200006 | - |
dc.identifier.doi | 10.3350/cmh.2015.21.1.32 | - |
dc.identifier.bibliographicCitation | CLINICAL AND MOLECULAR HEPATOLOGY, v.21, no.1, pp.32 - 40 | - |
dc.identifier.kciid | ART001972750 | - |
dc.identifier.scopusid | 2-s2.0-85050580549 | - |
dc.citation.endPage | 40 | - |
dc.citation.startPage | 32 | - |
dc.citation.title | CLINICAL AND MOLECULAR HEPATOLOGY | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Yo, In Ku | - |
dc.contributor.affiliatedAuthor | Kwon, Oh Sang | - |
dc.contributor.affiliatedAuthor | Park, Jin Woong | - |
dc.contributor.affiliatedAuthor | Lee, Jong Joon | - |
dc.contributor.affiliatedAuthor | Lee, Jung Hyun | - |
dc.contributor.affiliatedAuthor | Won, In Sik | - |
dc.contributor.affiliatedAuthor | Na, Sun Young | - |
dc.contributor.affiliatedAuthor | Jang, Pil Kyu | - |
dc.contributor.affiliatedAuthor | Park, Pyung Hwa | - |
dc.contributor.affiliatedAuthor | Choi, Duck Joo | - |
dc.contributor.affiliatedAuthor | Kim, Yun Soo | - |
dc.contributor.affiliatedAuthor | Kim, Ju Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Chronic hepatitis B | - |
dc.subject.keywordAuthor | Hepatic fibrosis | - |
dc.subject.keywordAuthor | Liver stiffness | - |
dc.subject.keywordAuthor | Transient elastography | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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