Determination of a novel phosphodiesterase4 inhibitor, 3-[1-(3cyclopropylmethoxy-4-difluoromethoxybenzyl)-1H-pyrazol-3-yl]benzoic acid (PDE-423) in rat plasma using liquid chromatography-tandem mass spectrometry
DC Field | Value | Language |
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dc.contributor.author | Cho, Woon-Ki | - |
dc.contributor.author | Seo, Hyewon | - |
dc.contributor.author | Choi, Sung Heum | - |
dc.contributor.author | Kwak, Hyun Jeong | - |
dc.contributor.author | Cheon, Hyae Gyeong | - |
dc.contributor.author | Jeon, Dong Ju | - |
dc.contributor.author | Kim, Sang Kyum | - |
dc.contributor.author | Bae, Myung Ae | - |
dc.contributor.author | Song, Jin Sook | - |
dc.date.available | 2020-02-28T10:41:31Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 0269-3879 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10742 | - |
dc.description.abstract | A method for determining a novel phosphodiesterase-4 inhibitor, 3-[1-(3cyclopropylmethoxy-4-difluoromethoxybenzyl)-1H-pyrazol-3-yl]-benzoic acid (PDE-423), in rat plasma was developed and validated using liquid chromatography-tandem mass spectrometry for further pharmacokinetic study for development as a novel anti-asthmatic drug. PDE-423 in the concentration range of 0.02-10 mu g/mL was linear with a correlation coefficient of >0.99, and the mean intra- and inter-assay precisions of the assay were 7.50 and 3.86%, respectively. The validated method was used successfully for a pharmacokinetic study of PDE-423 in rats. Copyright (c) 2014 John Wiley & Sons, Ltd. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | BIOMEDICAL CHROMATOGRAPHY | - |
dc.subject | DISCOVERY | - |
dc.title | Determination of a novel phosphodiesterase4 inhibitor, 3-[1-(3cyclopropylmethoxy-4-difluoromethoxybenzyl)-1H-pyrazol-3-yl]benzoic acid (PDE-423) in rat plasma using liquid chromatography-tandem mass spectrometry | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000347825800001 | - |
dc.identifier.doi | 10.1002/bmc.3280 | - |
dc.identifier.bibliographicCitation | BIOMEDICAL CHROMATOGRAPHY, v.29, no.3, pp.321 - 324 | - |
dc.identifier.scopusid | 2-s2.0-84920988756 | - |
dc.citation.endPage | 324 | - |
dc.citation.startPage | 321 | - |
dc.citation.title | BIOMEDICAL CHROMATOGRAPHY | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kwak, Hyun Jeong | - |
dc.contributor.affiliatedAuthor | Cheon, Hyae Gyeong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | PDE-423 | - |
dc.subject.keywordAuthor | method validation | - |
dc.subject.keywordAuthor | pharmacokinetics | - |
dc.subject.keywordAuthor | LC-MS/MS | - |
dc.subject.keywordAuthor | rat plasma | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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