Bioreducible Shell-Cross-Linked Hyaluronic Acid Nanoparticles for Tumor-Targeted Drug Delivery
DC Field | Value | Language |
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dc.contributor.author | Han, Hwa Seung | - |
dc.contributor.author | Thambi, Thavasyappan | - |
dc.contributor.author | Choi, Ki Young | - |
dc.contributor.author | Son, Soyoung | - |
dc.contributor.author | Ko, Hyewon | - |
dc.contributor.author | Lee, Min Chang | - |
dc.contributor.author | Jo, Dong-Gyu | - |
dc.contributor.author | Chae, Yee Soo | - |
dc.contributor.author | Kang, Young Mo | - |
dc.contributor.author | Lee, Jun Young | - |
dc.contributor.author | Park, Jae Hyung | - |
dc.date.available | 2020-02-28T10:42:53Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10812 | - |
dc.description.abstract | The major issues of self-assembled nanoparticles as drug carriers for cancer therapy include biostability and tumor-targetability because the premature drug release from and nonspecific accumulation of the drug-loaded nanoparticles may cause undesirable toxicity to normal organs and lower therapeutic efficacy. In this study, we developed robust and tumor-targeted nanocarriers based on an amphiphilic hyaluronic acid (HA)-polycaprolactone (PCL) block copolymer, in which the HA shell was cross-linked via a bioreducible disulfide linkage. Doxorubicin (DOX), chosen as a model anticancer drug, was effectively encapsulated into the nanoparticles with high drug loading efficiency. The DOX-loaded bioreducible HA nanoparticles (DOX-HA-ss-NPs) greatly retarded the drug release under physiological conditions (pH 7.4), whereas the drug release rate was markedly enhanced in the presence of glutathione, a thiol-containing tripeptide capable of reducing disulfide bonds in the cytoplasm. Furthermore, DOX-HA-ss-NPs could effectively deliver the DOX into the nuclei of SCC7 cells in vitro as well as to tumors in vivo after systemic administration into SCC7 tumor-bearing mice, resulting in improved antitumor efficacy in tumor-bearing mice. Overall, it was demonstrated that bioreducible shell-cross-linked nanoparticles could be used as a potential carrier for cancer therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | BIOMACROMOLECULES | - |
dc.subject | BLOCK-COPOLYMER MICELLES | - |
dc.subject | IN-VIVO STABILITY | - |
dc.subject | INTRACELLULAR DELIVERY | - |
dc.subject | POLYMERIC MICELLES | - |
dc.subject | ACCUMULATION | - |
dc.subject | NANOCARRIERS | - |
dc.subject | DOXORUBICIN | - |
dc.subject | NANOSTRUCTURES | - |
dc.subject | LIPOSOMES | - |
dc.subject | PROTEINS | - |
dc.title | Bioreducible Shell-Cross-Linked Hyaluronic Acid Nanoparticles for Tumor-Targeted Drug Delivery | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000349273000003 | - |
dc.identifier.doi | 10.1021/bm5017755 | - |
dc.identifier.bibliographicCitation | BIOMACROMOLECULES, v.16, no.2, pp.447 - 456 | - |
dc.identifier.scopusid | 2-s2.0-84922544250 | - |
dc.citation.endPage | 456 | - |
dc.citation.startPage | 447 | - |
dc.citation.title | BIOMACROMOLECULES | - |
dc.citation.volume | 16 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Lee, Min Chang | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER MICELLES | - |
dc.subject.keywordPlus | IN-VIVO STABILITY | - |
dc.subject.keywordPlus | INTRACELLULAR DELIVERY | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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