Role of the focal adhesion protein TRIM15 in colon cancer development
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ok-Hee | - |
dc.contributor.author | Lee, Jinkyoung | - |
dc.contributor.author | Lee, Keun Ho | - |
dc.contributor.author | Woo, Yun Mi | - |
dc.contributor.author | Kang, Ju-Hee | - |
dc.contributor.author | Yoon, Ho-Geun | - |
dc.contributor.author | Bae, Soo-Kyung | - |
dc.contributor.author | Songyang, Zhou | - |
dc.contributor.author | Oh, Seung Hyun | - |
dc.contributor.author | Choi, Youngsok | - |
dc.date.available | 2020-02-28T10:43:07Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 0167-4889 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10822 | - |
dc.description.abstract | The tripartite motif containing (TRIM) proteins are a large family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation, and signaling pathways. Here, we show that TRIM15 co-localized to focal adhesions through homo-dimerization and significantly suppressed cell migration. Domain mapping analysis indicated that B-box2 and PRY domains were essential for TRIM15 localization to focal adhesions and inhibition of cell migration. Our protein-protein interaction screen of TRIM15 with the integrin adhesome identified several TRIM15 interacting proteins including coronin 18, cortactin, filamin binding LIM protein1, and vasodilator-stimulated phosphoprotein, which are involved in actin cytoskeleton dynamics. TRIM15 expression was tissue-restricted and downregulated in colon cancer. Level of TRIM15 expression was associated with colon cancer cell migration, as well as both in vitro and in vivo tumor growth. These data provide novel insights into the role of TRIM15 as an additional component of the integrin adhesome, regulating cell migration, and suggest that TRIM15 may function as a tumor suppressor of colon cancer. (C) 2014 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - |
dc.subject | CELL | - |
dc.subject | CORTACTIN | - |
dc.subject | MOTIF | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | NISCHARIN | - |
dc.title | Role of the focal adhesion protein TRIM15 in colon cancer development | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000348554600015 | - |
dc.identifier.doi | 10.1016/j.bbamcr.2014.11.007 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v.1853, no.2, pp.409 - 421 | - |
dc.identifier.scopusid | 2-s2.0-84914166653 | - |
dc.citation.endPage | 421 | - |
dc.citation.startPage | 409 | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - |
dc.citation.volume | 1853 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Kang, Ju-Hee | - |
dc.contributor.affiliatedAuthor | Oh, Seung Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | TRIM15 | - |
dc.subject.keywordAuthor | Colon cancer | - |
dc.subject.keywordAuthor | Focal adhesion | - |
dc.subject.keywordAuthor | Cell migration | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | CORTACTIN | - |
dc.subject.keywordPlus | MOTIF | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | NISCHARIN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.