Abietic acid inhibits UVB-induced MMP-1 expression in human dermal fibroblast cells through PPAR alpha/gamma dual activation
DC Field | Value | Language |
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dc.contributor.author | Jeon, Youngsic | - |
dc.contributor.author | Jung, Yujung | - |
dc.contributor.author | Youm, Jong-Kyung | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Yong Kee | - |
dc.contributor.author | Kim, Su-Nam | - |
dc.date.available | 2020-02-28T10:43:14Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10828 | - |
dc.description.abstract | Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors and consist of three isotypes: PPAR, PPAR/ and PPAR. PPARs are expressed in various cell types in the skin, including keratinocytes, fibroblasts and infiltrating immune cells. Thus, these receptors are highly studied in dermato-endocrine research, and their ligands are targets for the treatment of various skin disorders, such as photoageing and chronological ageing of skin. Intensive studies have revealed that PPAR/ functions in photoageing and age-related inflammation by regulating matrix metalloproteinases (MMPs) via nuclear factor-kappa B (NF-B) and activator protein-1 (AP-1). However, the detailed mechanism of PPAR/'s role in photoageing has not yet been elucidated. In this study, we confirmed that abietic acid (AA) is a PPAR/ dual ligand and significantly decreased UVB-induced MMP-1 expression by downregulating UVB-induced MAPK signalling and downstream transcription factors, subsequently reducing IB degradation and blocking NF-B p65 nuclear translocation in Hs68 human dermal fibroblast cells. Treatment of cells with AA and GW6471 or bisphenol A diglycidyl ether (BADGE), PPAR or PPAR antagonists, respectively, reversed the effect on UVB-induced MMP-1 expression and inflammatory signalling pathway activation. Taken together, our data suggest that AA acts as a PPAR/ dual activator to inhibit UVB-induced MMP-1 expression and age-related inflammation by suppressing NF-B and the MAPK/AP-1 pathway and can be a useful agent for improving skin photoageing. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | EXPERIMENTAL DERMATOLOGY | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | PEROXISOME-PROLIFERATOR | - |
dc.subject | LIPID-METABOLISM | - |
dc.subject | INFLAMMATION | - |
dc.subject | RECEPTORS | - |
dc.subject | RADIATION | - |
dc.subject | ALPHA | - |
dc.subject | GAMMA | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | PATHWAYS | - |
dc.title | Abietic acid inhibits UVB-induced MMP-1 expression in human dermal fibroblast cells through PPAR alpha/gamma dual activation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000348911700013 | - |
dc.identifier.doi | 10.1111/exd.12616 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL DERMATOLOGY, v.24, no.2, pp.140 - 145 | - |
dc.identifier.scopusid | 2-s2.0-84930402968 | - |
dc.citation.endPage | 145 | - |
dc.citation.startPage | 140 | - |
dc.citation.title | EXPERIMENTAL DERMATOLOGY | - |
dc.citation.volume | 24 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | abietic acid | - |
dc.subject.keywordAuthor | AP-1 | - |
dc.subject.keywordAuthor | MMPs | - |
dc.subject.keywordAuthor | NF-beta B | - |
dc.subject.keywordAuthor | PPAR alpha/gamma | - |
dc.subject.keywordAuthor | dual activator | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | PEROXISOME-PROLIFERATOR | - |
dc.subject.keywordPlus | LIPID-METABOLISM | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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