Statin use has negative clinical impact on non-germinal center in patients with diffuse large B cell lymphoma in rituximab era
DC Field | Value | Language |
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dc.contributor.author | Song, Moo-Kon | - |
dc.contributor.author | Chung, Joo-Seop | - |
dc.contributor.author | Lee, Gyeong-Won | - |
dc.contributor.author | Cho, Su-Hee | - |
dc.contributor.author | Hong, Junshik | - |
dc.contributor.author | Shin, Dong-Yeop | - |
dc.contributor.author | Shin, Ho-Jin | - |
dc.date.available | 2020-02-28T10:43:16Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 0145-2126 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10830 | - |
dc.description.abstract | Rituximab improved prognosis in diffuse large B cell lymphoma (DLBCL). However, activity of rituximab may be reduced by conformational change in CD20 by statin-induced cholesterol depletion. Conformation change in CD20 could impair the binding of rituximab and significantly decrease the killing effect of lymphoma cells. R-CHOP therapy could counteract the prognostic gap between GC type and non-GC type. We investigated whether statin use could have different clinical impacts on immunohistochemical DLBCL subtypes in the rituximab era. We analyzed data from 409 patients with de novo DLBCL who received R-CHOP therapy. During median follow-up time of 38.6 months, 3-year progression-free survival (PFS) and overall survival (OS) in the GC type were similar to those in the non-GC type (PFS, p = 0.125; OS, p = 0.201). Moreover, survivals were comparable between patients with statin therapy and those without the statin therapy (PFS, p = 0.282; OS, p=0.273). We also analyzed whether statin therapy would have clinical significance by immunophenotypes in patients treated with R-CHOP therapy. The non-GC type with statin therapy had inferior PFS and OS compared to other groups (PFS, p = 0.008; OS, p = 0.006). In multivariate analysis, statin therapy had significant negative impacts on survivals of the non-GC type independent of other clinical factors (PFS, hazard ratio/HR: 1.553, 95% CI: 1.058-2.279, p = 0.024; OS, HR= 1.532, 95% CI: 1.041-2.255, p =0.023). Therefore, statin therapy negatively affected the clinical outcome of the non-GC phenotype, but it was beneficial to R-CHOP therapy in DLBCL. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | LEUKEMIA RESEARCH | - |
dc.subject | NON-HODGKINS-LYMPHOMA | - |
dc.subject | CHEMOTHERAPY IMPROVES | - |
dc.subject | PROGNOSTIC IMPACT | - |
dc.subject | SURVIVAL | - |
dc.subject | THERAPY | - |
dc.subject | CHOP | - |
dc.title | Statin use has negative clinical impact on non-germinal center in patients with diffuse large B cell lymphoma in rituximab era | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000348290400016 | - |
dc.identifier.doi | 10.1016/j.leukres.2014.12.003 | - |
dc.identifier.bibliographicCitation | LEUKEMIA RESEARCH, v.39, no.2, pp.211 - 215 | - |
dc.identifier.scopusid | 2-s2.0-84921434023 | - |
dc.citation.endPage | 215 | - |
dc.citation.startPage | 211 | - |
dc.citation.title | LEUKEMIA RESEARCH | - |
dc.citation.volume | 39 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Hong, Junshik | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Rituximab | - |
dc.subject.keywordAuthor | Diffuse large B cell lymphoma | - |
dc.subject.keywordAuthor | Statin | - |
dc.subject.keywordAuthor | Germinal center | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | CHEMOTHERAPY IMPROVES | - |
dc.subject.keywordPlus | PROGNOSTIC IMPACT | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CHOP | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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