Vegetable peptones increase production of type I collagen in human fibroblasts by inducing the RSK-CCAAT/enhancer binding protein-beta phosphorylation pathway
- Authors
- Jung, Eunsun; Cho, Jae Youl; Park, Deokhoon; Kim, Min Hee; Park, Beomseok; Lee, Sang Yeol; Lee, Jongsung
- Issue Date
- Feb-2015
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Cell proliferation; Type I procollagen; Vegetable peptones; RSK pathway; Skin aging; Human dermal fibroblasts
- Citation
- NUTRITION RESEARCH, v.35, no.2, pp.127 - 135
- Journal Title
- NUTRITION RESEARCH
- Volume
- 35
- Number
- 2
- Start Page
- 127
- End Page
- 135
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10833
- DOI
- 10.1016/j.nutres.2014.10.011
- ISSN
- 0271-5317
- Abstract
- Skin aging appears to be principally attributed to a decrease in type I collagen level and the regeneration ability of dermal fibroblasts. We hypothesized that vegetable peptones promote cell proliferation and production of type I collagen in human dermal fibroblasts. Therefore, we investigated the effects of vegetable peptones on cell proliferation and type I collagen production and their possible mechanisms in human dermal fibroblasts. Vegetable peptones significantly promoted cell proliferation in a concentration-dependent manner. In addition, the human luciferase type I collagen alpha 2 promoter and type I procollagen synthesis assays showed that the vegetable peptones induced type I procollagen production by activating the type I collagen alpha 2 promoter. Moreover, the vegetable peptones activated p90 ribosomal s6 kinase, which was mediated by activating the Raf-p44/42 mitogen-activated protein kinase signaling pathway. Furthermore, the vegetable peptone-induced increase in cell proliferation and type I collagen production decreased upon treatment with the ERK inhibitor PD98059. Taken together, these findings suggest that increased proliferation of human dermal fibroblasts and enhanced production of type I collagen by vegetable peptones occur primarily by inducing the p90 ribosomal s6 kinase-CCAAT/enhancer binding protein beta phosphorylation pathway, which is mediated by activating Raf-ERK signaling. (C) 2015 Elsevier Inc. All rights reserved.
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