Fucoidan from Fucus vesiculosus Protects against Alcohol-Induced Liver Damage by Modulating Inflammatory Mediators in Mice and HepG2 Cells
DC Field | Value | Language |
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dc.contributor.author | Lim, Jung Dae | - |
dc.contributor.author | Lee, Sung Ryul | - |
dc.contributor.author | Kim, Taeseong | - |
dc.contributor.author | Jang, Seon-A | - |
dc.contributor.author | Kang, Se Chan | - |
dc.contributor.author | Koo, Hyun Jung | - |
dc.contributor.author | Sohn, Eunsoo | - |
dc.contributor.author | Bak, Jong Phil | - |
dc.contributor.author | Namkoong, Seung | - |
dc.contributor.author | Kim, Hyoung Kyu | - |
dc.contributor.author | Song, In Sung | - |
dc.contributor.author | Kim, Nari | - |
dc.contributor.author | Sohn, Eun-Hwa | - |
dc.contributor.author | Han, Jin | - |
dc.date.available | 2020-02-28T10:43:20Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10835 | - |
dc.description.abstract | Fucoidan is an l-fucose-enriched sulfated polysaccharide isolated from brown algae and marine invertebrates. In this study, we investigated the protective effect of fucoidan from Fucus vesiculosus on alcohol-induced murine liver damage. Liver injury was induced by oral administration of 25% alcohol with or without fucoidan (30 mg/kg or 60 mg/kg) for seven days. Alcohol administration increased serum aspartate aminotransferase and alanine aminotransferase levels, but these increases were suppressed by the treatment of fucoidan. Transforming growth factor beta 1 (TGF-beta 1), a liver fibrosis-inducing factor, was highly expressed in the alcohol-fed group and human hepatoma HepG2 cell; however, the increase in TGF-beta 1 expression was reduced following fucoidan administration. Treatment with fucoidan was also found to significantly reduce the production of inflammation-promoting cyclooygenase-2 and nitric oxide, while markedly increasing the expression of the hepatoprotective enzyme, hemeoxygenase-1, on murine liver and HepG2 cells. Taken together, the antifibrotic and anti-inflammatory effects of fucoidan on alcohol-induced liver damage may provide valuable insights into developing new therapeutics or interventions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | MARINE DRUGS | - |
dc.subject | GROWTH-FACTOR-BETA | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | RAT-LIVER | - |
dc.subject | CARBON-MONOXIDE | - |
dc.subject | FIBROSIS | - |
dc.subject | DISEASE | - |
dc.subject | INJURY | - |
dc.subject | PATHWAY | - |
dc.subject | CYCLOOXYGENASE-2 | - |
dc.title | Fucoidan from Fucus vesiculosus Protects against Alcohol-Induced Liver Damage by Modulating Inflammatory Mediators in Mice and HepG2 Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000350217500023 | - |
dc.identifier.doi | 10.3390/md13021051 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.13, no.2, pp.1051 - 1067 | - |
dc.identifier.scopusid | 2-s2.0-84923261249 | - |
dc.citation.endPage | 1067 | - |
dc.citation.startPage | 1051 | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Jang, Seon-A | - |
dc.contributor.affiliatedAuthor | Kang, Se Chan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Alcohol | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | Fucoidan | - |
dc.subject.keywordAuthor | Liver | - |
dc.subject.keywordAuthor | Transforming growth factor beta 1 | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | RAT-LIVER | - |
dc.subject.keywordPlus | CARBON-MONOXIDE | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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