Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus
DC Field | Value | Language |
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dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Park, Yong Joo | - |
dc.contributor.author | Moon, Eunjung | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Lee, Jei Hyun | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T10:44:06Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-01-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10870 | - |
dc.description.abstract | A bioassay-guided fractionation and chemical investigation of the MeOH extract of Raphanus sativus seeds resulted in the isolation and identification of eight phenylpropanoid sucrosides (1-8) including two new compounds, named raphasativuside A and B (1-2) from the most active CHCl3-soluble fraction. The structures of these new compounds were elucidated through spectral analysis, including extensive 2D-NMR data, and chemical reaction experiments. We evaluated the anti-inflammatory effects of 1-8 in lipopolysaccharide (LPS)-stimulated murine microglia BV2 cells. Compounds 2 and 5 exhibited significant inhibitory effect on nitric oxide production in LPS-activated BV-2 cells with IC50 values of 21.63 and 26.96 mu M, respectively. All isolates were also evaluated for their antiproliferative activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15). Compounds 1-7 showed consistent cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values of 6.71-27.92 mu M. Additionally, the free-radical scavenging activity of 1-8 was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay where compounds 1, 3, and 4 scavenged DPPH radical strongly with IC50 values of 23.05, 27.10, and 29.63 mu g/mL, respectively. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.subject | GLYCOSIDES | - |
dc.subject | DERIVATIVES | - |
dc.subject | LEAVES | - |
dc.subject | ANALOGS | - |
dc.subject | ESTERS | - |
dc.title | Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000345581600019 | - |
dc.identifier.doi | 10.1016/j.bmcl.2014.11.001 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.1, pp.96 - 99 | - |
dc.identifier.scopusid | 2-s2.0-84913528970 | - |
dc.citation.endPage | 99 | - |
dc.citation.startPage | 96 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Moon, Eunjung | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Raphanus sativus | - |
dc.subject.keywordAuthor | Brassicaceae | - |
dc.subject.keywordAuthor | Sucrose derivatives | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Antioxidant activity | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | ESTERS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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