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The synthesis of sulforaphane analogues and their protection effect against cisplatin induced cytotoxicity in kidney cells

Authors
Kim, TaejungKim, Young-JooHan, Im-HoLee, DahaeHam, JungyeobKang, Ki SungLee, Jae Wook
Issue Date
1-Jan-2015
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Sulforaphane; Cisplatin induced kidney disease; Kidney protection; Reactive oxygen species; Isothiocyanate
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.1, pp.62 - 66
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume
25
Number
1
Start Page
62
End Page
66
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10872
DOI
10.1016/j.bmcl.2014.11.014
ISSN
0960-894X
Abstract
A series of sulforaphane analogues were synthesized with various amines by treatment of carbon disulfide followed by Boc(2)O and DMAP. These synthesized sulforaphane analogues were tested on cisplatin treated cultured LLC-PK1 kidney cell line. Among these analogues, several compounds including SF5 show a potent effect on kidney cell protection assay at the concentration of 2.5 mu M. Further studies with compound SF5 revealed that the kidney cell protection effect was related by inhibiting the apoptosis pathway through JNK-p53-caspase apoptotic cascade. Compound SF5 may be considered as a promising candidate for the development of new kidney protection agent against drug induced acute kidney disease. (C) 2014 Elsevier Ltd. All rights reserved.
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Kang, Ki Sung
College of Korean Medicine (Premedical course of Oriental Medicine)
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