Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhou, Linkang | - |
dc.contributor.author | Park, Shi-Young | - |
dc.contributor.author | Xu, Li | - |
dc.contributor.author | Xia, Xiayu | - |
dc.contributor.author | Ye, Jing | - |
dc.contributor.author | Su, Lu | - |
dc.contributor.author | Jeong, Kyeong-Hoon | - |
dc.contributor.author | Hur, Jang Ho | - |
dc.contributor.author | Oh, Hyunhee | - |
dc.contributor.author | Tamori, Yoshikazu | - |
dc.contributor.author | Zingaretti, Cristina M. | - |
dc.contributor.author | Cinti, Saverio | - |
dc.contributor.author | Argente, Jesus | - |
dc.contributor.author | Yu, Miao | - |
dc.contributor.author | Wu, Lizhen | - |
dc.contributor.author | Ju, Shenghong | - |
dc.contributor.author | Guan, Feifei | - |
dc.contributor.author | Yang, Hongyuan | - |
dc.contributor.author | Choi, Cheol Soo | - |
dc.contributor.author | Savage, David B. | - |
dc.contributor.author | Li, Peng | - |
dc.date.available | 2020-02-28T10:44:18Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10882 | - |
dc.description.abstract | Fsp27 is a lipid droplet-associated protein almost exclusively expressed in adipocytes where it facilitates unilocular lipid droplet formation. In mice, Fsp27 deficiency is associated with increased basal lipolysis, 'browning' of white fat and a healthy metabolic profile, whereas a patient with congenital CIDEC deficiency manifested an adverse lipodystrophic phenotype. Here we reconcile these data by showing that exposing Fsp27-null mice to a substantial energetic stress by crossing them with ob/ob mice or BATless mice, or feeding them a high-fat diet, results in hepatic steatosis and insulin resistance. We also observe a striking reduction in adipose inflammation and increase in adiponectin levels in all three models. This appears to reflect reduced activation of the inflammasome and less adipocyte death. These findings highlight the importance of Fsp27 in facilitating optimal energy storage in adipocytes and represent a rare example where adipose inflammation and hepatic insulin resistance are disassociated. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.subject | FAT-SPECIFIC PROTEIN-27 | - |
dc.subject | BIOLOGICAL PATHWAYS | - |
dc.subject | GENETIC ABLATION | - |
dc.subject | LIPID DROPLETS | - |
dc.subject | DEFICIENT MICE | - |
dc.subject | KNOCKOUT MICE | - |
dc.subject | MOUSE MODELS | - |
dc.subject | FACTOR-ALPHA | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | OBESE MICE | - |
dc.title | Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000348810700005 | - |
dc.identifier.doi | 10.1038/ncomms6949 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.6 | - |
dc.identifier.scopusid | 2-s2.0-84931289926 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Park, Shi-Young | - |
dc.contributor.affiliatedAuthor | Jeong, Kyeong-Hoon | - |
dc.contributor.affiliatedAuthor | Hur, Jang Ho | - |
dc.contributor.affiliatedAuthor | Oh, Hyunhee | - |
dc.contributor.affiliatedAuthor | Choi, Cheol Soo | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FAT-SPECIFIC PROTEIN-27 | - |
dc.subject.keywordPlus | BIOLOGICAL PATHWAYS | - |
dc.subject.keywordPlus | GENETIC ABLATION | - |
dc.subject.keywordPlus | LIPID DROPLETS | - |
dc.subject.keywordPlus | DEFICIENT MICE | - |
dc.subject.keywordPlus | KNOCKOUT MICE | - |
dc.subject.keywordPlus | MOUSE MODELS | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | OBESE MICE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.