Analysis of ImmunoCAP® ISAC results of chronic spontaneous urticaria patients: Comparison with skin prick and the MAST-EIA tests
DC Field | Value | Language |
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dc.contributor.author | Kim, J.-H. | - |
dc.contributor.author | Roh, J.-Y. | - |
dc.contributor.author | Lee, J.-R. | - |
dc.date.available | 2020-02-28T11:41:23Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11058 | - |
dc.description.abstract | Background: In vivo and/or in vitro diagnostic tests to identify possible allergens have been conducted for patients with chronic spontaneous urticaria (CSU) in order to identify any predisposing factors and avoid unnecessary restrictions. Objective: The purpose of this study was to evaluate the diagnostic effectiveness of ImmunoCAP® ISAC (ISAC) in CSU patients. Methods: A total of 31 patients with CSU were tested by ISAC and Multiple Allergen Simultaneous Test enzyme immunoassays (MAST-EIA). A skin prick test (SPT) was performed for 17 out of 31 patients. The results of ISAC and MAST-EIA were evaluated based on the SPT results. Results: For 17 patients, with SPT used as the reference standard, ISAC compared with MAST-EIA showed lower sensitivity (22.2% vs. 26.5%), higher specificity (100% vs. 95.7%), higher positive predictive value (100% vs. 52.9%), and lower negative predictive value (86.9% vs. 87.7%). The agreement rate was more favorable for ISAC than for MAST-EIA (87.3% vs. 85.1%; kappa=0.324 vs. 0.263). For 31 patients, the agreement rate between ISAC and MAST-EIA was 83.9% for both Dermatophagoides farinae and Dermatophagoides pteronyssinus. Correlation coefficients (Rho) between ISAC and MAST-EIA for each allergen were 0.690 and 0.675, respectively. Conclusion: For CSU patients, specificity, positive predictive value, and the agreement rate of ISAC were similar or superior to those of MAST-EIA. In addition, ISAC provides valuable information on the possible sensitization to different allergen sources by elucidating cross-reactive components. With careful clinical correlations in interpretation, ISAC can be a useful diagnostic tool to detect allergens in CSU patients. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.language.iso | ko | - |
dc.publisher | Korean Dermatological Association | - |
dc.relation.isPartOf | Korean Journal of Dermatology | - |
dc.title | Analysis of ImmunoCAP® ISAC results of chronic spontaneous urticaria patients: Comparison with skin prick and the MAST-EIA tests | - |
dc.title.alternative | 만성 두드러기 환자에서 ImmunoCAPⓇ ISAC 검사에 의한 알레르겐 특이항체 검사 유용성의 분석: 피부단자시험 및MAST-EIA 검사와의 비교 연구 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology, v.53, no.9, pp.684 - 692 | - |
dc.identifier.kciid | ART002053082 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84979243555 | - |
dc.citation.endPage | 692 | - |
dc.citation.startPage | 684 | - |
dc.citation.title | Korean Journal of Dermatology | - |
dc.citation.volume | 53 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Kim, J.-H. | - |
dc.contributor.affiliatedAuthor | Roh, J.-Y. | - |
dc.contributor.affiliatedAuthor | Lee, J.-R. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Chronic spontaneous urticaria | - |
dc.subject.keywordAuthor | ImmunoCAP®ISAC | - |
dc.subject.keywordAuthor | MAST-EIA | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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