Eosinophils are required for immune responses induced by oral immunization
- Authors
- Jung, Y.
- Issue Date
- 2015
- Publisher
- The Korean Society for Mocrobiology / The Korean Society of Virology
- Keywords
- Antibody responses; Eosinophils; Mucosal immunity; Oral immunization; Small intestine
- Citation
- Journal of Bacteriology and Virology, v.45, no.4, pp.354 - 363
- Journal Title
- Journal of Bacteriology and Virology
- Volume
- 45
- Number
- 4
- Start Page
- 354
- End Page
- 363
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11061
- DOI
- 10.4167/jbv.2015.45.4.354
- ISSN
- 1598-2467
- Abstract
- Eosinophils are multifunctional leukocytes that reside in several tissues, most abundantly in the small intestinal lamina propria under the steady state. To date, the phenotypic and functional characteristics of small intestinal eosinophils have remained poorly understood. In this study, we found that proliferation of ovalbumin (OVA)-specific CD4+ T cells isolated from the mesenteric lymph nodes of eosinophil-deficient ∆dblGATA mice were decreased relative to wild-type mice after oral immunization with OVA and cholera toxin (CT), the typical mucosal adjuvant that induces CD4+ T cell-dependent responses. ∆dblGATA mice showed reduced mucosal secretion of OVA-specific IgA and IgG1 while maintaining a systemic level of anti-OVA IgG1 upon oral immunization with OVA and CT. These findings suggest that eosinophils might have a role in the modulation of T cell-mediated immune responses including mucosal antibody responses in the gastrointestinal tract following oral immunization. © 2015, Chonnam National University Medical School. All rights Reserved.
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