갑상선유두암에서 p53과 Cyclin D1의 발현이 가지는 예후인자로서의 의미Prognostic Value of p53 and Cyclin D1 in Papillary Thyroid Carcinoma
- Other Titles
- Prognostic Value of p53 and Cyclin D1 in Papillary Thyroid Carcinoma
- Authors
- 석재연; 정동해; 정유승; 류정원; 이영돈
- Issue Date
- Jun-2015
- Publisher
- 대한갑상선-내분비외과학회
- Keywords
- 갑상선유두암; p53; Cyclin D1; 예후; 림프절 전이율; Papillary thyroid carcinoma; p53; Cyclin D1; Prognosis; Lymph node metasta-tic ratio
- Citation
- The Journal of Endocrine Surgery, v.15, no.2, pp.25 - 33
- Journal Title
- The Journal of Endocrine Surgery
- Volume
- 15
- Number
- 2
- Start Page
- 25
- End Page
- 33
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11539
- ISSN
- 2508-8149
- Abstract
- Purpose: P53 and cyclin D1 have been evaluated as a prognostic marker in papillary thyroid carcinoma (PTC). However, the relationship between p53/cyclin D1 and PTC prognosis has not yet been confirmed. Therefore, we investigated the relationship between p53/cyclin D1 and PTC prognostic factors.Methods: 919 patients with PTC were enrolled. Immunohistochemistry slides were reviewed for p53 and cyclin D1 immunoreactivity. Patients were classified into two groups according to the p53 and cyclin D1 grade: negative for ≤5% and positive for >5%. Medical records were reviewed to evaluate the prognostic factors, lymph node metastatic ratio (LNMR), and MACIS score. We analyzed patients based on p53/cyclin D1(−/−), p53/cyclin D1(−/+), p53/cyclin D1(+/−), p53/cyclin D1(+/+) separately for evaluation of independent effect of p53 and cyclin D1.Results: Mean age of the patients was 49.73 years (range 15∼87), and tumor size was 1.19 cm (range 0.1∼5.0). P53 was positive in 809 (88.0%) and cyclin D1 was positive in 748 (81.4%). Positivity of p53 and cyclin D1 were correlated (r=0.448). There was no statistical significance in MACIS score. Positivity of p53 and cyclin D1 were related with larger tumor size, older age, early T stage, more tumor capsulation, and female. LNMR was higher in p53/cyclin D1(+/−) than p53/cyclin D1(−/−) (P=0.036), p53/cyclin D1(−/+) than p53/cyclin D1(−/−) (P=0.034), and p53/cyclin D1(+/+) than p53/cyclin D1(−/−) (P=0.007). Conclusion: There was no consistent relationship between p53/cyclin D1 and worse prognostic factors of PTC. However, LNMR was higher in p53(+) and cyclin D1(+) cases independently, much more in p53/cyclin D1(+/+) than p53/cyclin D1(−/−).
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